Document Detail


C cells in normal thyroid aspirates.
MedLine Citation:
PMID:  10432875     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To quantify C cells in normal thyroid aspirates. STUDY DESIGN: Smears of 18 glands from patients with no thyroid disease, 8 women and 10 men aged on average 52.8 years, were analyzed. Five samples were aspirated from the upper, middle and lower thirds of each lateral lobe and from the isthmus. Smears were stained with anticalcitonin monoclonal antibody. RESULTS: C cells were detected in all specimens, ranging in number from 3 to 19 per gland, with 53.4% of the cells in the right lobe, 42.8% in the left lobe and 3.7% in the isthmus. The aspirates from the right lobe had 0-13 cells in the upper third, 0-9 in the middle third and 0-3 in the lower third. In the left lobe aspirates there were 0-7 cells in the upper third, 0-6 in the middle third and 0-2 in the lower third. One to two C cells were observed in the isthmus in only four cases. CONCLUSION: It is possible to determine the presence of C cells in normal thyroids and confirm studies conducted on histologic material; the cells were more frequently detected in the middle and upper third and mainly on the right side. They were rare in the isthmus. The search for C cells in thyroid aspirates is of great importance because it permits one to confirm rapidly, precisely and minimally invasively cases suspected of C cell hyperplasia, a preneoplastic condition that precedes the development of medullary carcinoma. In addition, the method shows numerical changes in these cells in such conditions as Hashimoto's thyroiditis and colloid goiter, in which the present results could serve as a control.
Authors:
M A de Lima; B M Santos; F S Tiveron; M E de Abreu
Related Documents :
56235 - Quantitative changes of the c-cell population in the rat thyroid during postnatal ontog...
1113605 - Density of goblet cells in chronic secretory otitis media: findings in a biopsy material.
8554165 - G-protein activation enhances ca(2+)-dependent lipid secretion of the rat harderian gland.
417465 - C-cell in vestiges of the ultimobranchial body in human thyroid glands.
25058425 - Immortalised breast epithelia survive prolonged dna replication stress and return to cy...
4570775 - Microcinematographic studies of mycoplasma hominis cells.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta cytologica     Volume:  43     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    1999 Jul-Aug
Date Detail:
Created Date:  1999-08-16     Completed Date:  1999-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  558-62     Citation Subset:  IM    
Affiliation:
Faculty of Medicine, Triângulo Mineiro, Uberaba, Minas Gerais, Brazil. lima@mednet.com.br
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Cell Count
Cytodiagnosis / methods*
Female
Humans
Immunohistochemistry
Male
Middle Aged
Reference Values
Thyroid Gland / cytology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Features of benign granular cell tumor on fine needle aspiration.
Next Document:  Solitary nodular goiter. Review of cytomorphologic features in 441 cases.