Document Detail

C cells in normal thyroid aspirates.
MedLine Citation:
PMID:  10432875     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To quantify C cells in normal thyroid aspirates. STUDY DESIGN: Smears of 18 glands from patients with no thyroid disease, 8 women and 10 men aged on average 52.8 years, were analyzed. Five samples were aspirated from the upper, middle and lower thirds of each lateral lobe and from the isthmus. Smears were stained with anticalcitonin monoclonal antibody. RESULTS: C cells were detected in all specimens, ranging in number from 3 to 19 per gland, with 53.4% of the cells in the right lobe, 42.8% in the left lobe and 3.7% in the isthmus. The aspirates from the right lobe had 0-13 cells in the upper third, 0-9 in the middle third and 0-3 in the lower third. In the left lobe aspirates there were 0-7 cells in the upper third, 0-6 in the middle third and 0-2 in the lower third. One to two C cells were observed in the isthmus in only four cases. CONCLUSION: It is possible to determine the presence of C cells in normal thyroids and confirm studies conducted on histologic material; the cells were more frequently detected in the middle and upper third and mainly on the right side. They were rare in the isthmus. The search for C cells in thyroid aspirates is of great importance because it permits one to confirm rapidly, precisely and minimally invasively cases suspected of C cell hyperplasia, a preneoplastic condition that precedes the development of medullary carcinoma. In addition, the method shows numerical changes in these cells in such conditions as Hashimoto's thyroiditis and colloid goiter, in which the present results could serve as a control.
M A de Lima; B M Santos; F S Tiveron; M E de Abreu
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta cytologica     Volume:  43     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    1999 Jul-Aug
Date Detail:
Created Date:  1999-08-16     Completed Date:  1999-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  558-62     Citation Subset:  IM    
Faculty of Medicine, Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
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MeSH Terms
Aged, 80 and over
Cell Count
Cytodiagnosis / methods*
Middle Aged
Reference Values
Thyroid Gland / cytology*

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