| C-Type natriuretic peptide modulates pre- and postsynaptic properties in hippocampal area CA1 in vitro. | |
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MedLine Citation:
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PMID: 18952057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cGMP producing natriuretic peptide receptor B (NPR-B) and its ligand C-type natriuretic peptide (CNP) are widely distributed in the brain and are highly expressed in the hippocampal regions CA1-CA3. To date only limited functional data is available concerning the physiological effects of the peptide hormone in the hippocampus. Therefore, we were interested in how bath application of the peptide hormone might influence synaptic plasticity following high frequency stimulation (HFS). We found that CNP application decreased the population spike (PS) amplitude after HFS, thereby affecting long-term potentiation (LTP) in acute hippocampal slices. To investigate the molecular consequences of CNP application leading to a decrease in PS amplitude, we further analyzed the impact of the hormone on the number of presynaptic synapsin I clusters and number of postsynaptic AMPA receptor subunit GluR1 clusters as well as their co-localization in a primary hippocampal cell culture system. The observed pre-and postsynaptic effects after CNP stimulation of the cGMP pathway in hippocampal cell cultures may underlie the effect of the peptide hormone on LTP. |
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Authors:
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Jochen Martin Decker; Anna Wojtowicz; Uwe Heinemann; Karl-Heinz Braunewell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-24 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 377 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-25 Completed Date: 2008-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 820-5 Citation Subset: IM |
Affiliation:
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Institute for Neurophysiology, Johannes Müller Ctr. of Physiology, Charité-Universitätsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Hippocampus / drug effects, metabolism, physiology* Long-Term Potentiation* Natriuretic Peptide, C-Type / pharmacology, physiology* Rats Rats, Wistar Receptors, AMPA / metabolism Synapses / drug effects, physiology* Synapsins / metabolism Synaptic Potentials / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Receptors, AMPA; 0/Synapsins; 0/glutamate receptor ionotropic, AMPA 1; 127869-51-6/Natriuretic Peptide, C-Type |
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