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C-Reactive Protein: Re-evaluation of a Diagnostic Laboratory Test.
MedLine Citation:
PMID:  11105141     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
C-reactive protein has been a measure of acute phase reactions to inflammation for 40 years. Recently improved quantitative assays in serum and cerebrospinal fluid (CSF) have allowed a re-evaluation of its potential as a diagnostic laboratory test. The main advances in the newer methods have been that they can provide rapid (hours) information on the hepatocyte synthesis of this molecule during immune response. We have tested its value in patients with presumed bacterial meningitis. Based on our experience, newer standardized, quantitative assessments of C-reactive protein can be very useful in distinguishing between bacterial and other forms of meningeal irritation during the first few days of hospitalization. Other investigators have indicated that by serial measurements important information on the resolution or continuation of inflammatory processes can be obtained. We recommend improved standardization of this test, and recalculation of its usefulness as a diagnostic laboratory test.
Authors:
Ribeiro
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases     Volume:  1     ISSN:  1678-4391     ISO Abbreviation:  Braz J Infect Dis     Publication Date:  1997 Oct 
Date Detail:
Created Date:  2000-12-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812937     Medline TA:  Braz J Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  212-225     Citation Subset:  -    
Affiliation:
Adolfo Lutz Institute, São Paulo, Brazil.
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