Document Detail

C-reactive protein, interleukin 6, and N-terminal pro-brain natriuretic peptide following cardioversion of atrial fibrillation: is there a role of biomarkers in arrhythmia recurrence?
MedLine Citation:
PMID:  20834028     Owner:  NLM     Status:  MEDLINE    
AIMS: We investigated the role of high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), and N-terminal pro-brain natriuretic peptide (NTpro-BNP), in atrial fibrillation (AF) recurrence rate.
METHODS: A total of 80 patients with first AF episode were studied prospectively. Echocardiography (ECG), Holter ECG, and measurements of hsCRP, IL-6, and NTproBNP were performed immediately post conversion and at 1 month.
RESULTS: Recurrence was positively related to left atrial volume (P < .001), with no difference in NTpro-BNP, hsCRP, and IL-6. Decreased NTpro-BNP was observed in all at 1 month (P < .001, F = 63.4) and was positively related to left atrial volume (P < .01). In the lone AF subgroup, NTpro-BNP was lower and dropped significantly at 1 month (interaction F = 6.53, P < .01).
CONCLUSIONS: Atrial volume was related to AF recurrence, whereas hsCRP, IL-6, and NTpro-BNP were not reliable for AF relapse. Relation of NTpro-BNP to left atrial volume could indicate a role in the atrial remodeling process.
Stavroula N Psychari; Dionyssios Chatzopoulos; Efstathios K Iliodromitis; Thomas S Apostolou; Dimitrios T Kremastinos
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Publication Detail:
Type:  Journal Article     Date:  2010-09-11
Journal Detail:
Title:  Angiology     Volume:  62     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-08     Completed Date:  2011-06-28     Revised Date:  2011-11-10    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  310-6     Citation Subset:  IM    
Second Department of Cardiology, Nikea General Hospital, Athens, Greece.
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MeSH Terms
Analysis of Variance
Anti-Arrhythmia Agents / therapeutic use*
Atrial Fibrillation / blood*,  physiopathology,  therapy*,  ultrasonography
Biological Markers / blood
C-Reactive Protein / metabolism*
Chi-Square Distribution
Interleukin-6 / blood*
Middle Aged
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Prospective Studies
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Biological Markers; 0/Interleukin-6; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 9007-41-4/C-Reactive Protein
Comment In:
Angiology. 2011 Oct;62(7):590   [PMID:  21984261 ]

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