Document Detail


C-reactive protein/interleukin-6 ratio as marker of the size of the uncomplicated thoracic aortic aneurysms.
MedLine Citation:
PMID:  22843654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The role of C-reactive protein (CRP) and interleukin-6 (IL-6) as markers in the prognosis of asymptomatic thoracic aortic aneurysm (TAA) patients has not been well established. As such, we evaluated a group of patients for a possible association between serum CRP and IL-6 and aneurysm dimension.
METHODS: Serum CRP and IL-6 were determined and aneurysmal size was measured in 26 patients with TAA.
RESULTS: The mean (SD) CRP and IL-6 were 0.58 (1.07) and 7.47 (17.78) pg/ml, respectively. Serum CRP, IL-6 and the ratio CRP/IL-6 correlated with the descending aortic aneurysmal dimension (r = 0.426, r = 0.743 and r = 0.328, respectively). A significant correlation was also found between values of the ratio above 0.8 and aneurysmal dimension (both ascending and descending aneurysms) (r = 0.785). Additionally, a significant association between smoking, age group above 69 years and dyslipidemia and aneurysm dimension was established (P = 0.002, P = 0.061 and P = 0.070, respectively).
CONCLUSIONS: This report shows that serum CRP, IL-6 levels and the ratio CRP/IL-6 are associated with descending aortic aneurysmal dimensions. Also values of the ratio CRP/IL-6 above 0.8 are associated with aneurysmal dimensions for both ascending and descending aortic aneurysms. It is still early to establish the clinical significance of those findings, and further studies with larger groups of patients with longer follow-up are required in order to truly assess the usefulness of the serum CRP and IL-6 as markers in relation to the progression of the disease.
Authors:
Panagiotis Artemiou; Nicholas Charokopos; Efthymia Rouska; Frantisek Sabol; Ioannis Chrysogonidis; Vasiliki Tsavdaridou; Giannis Paschalidis
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Publication Detail:
Type:  Journal Article     Date:  2012-07-27
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  15     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-26     Completed Date:  2013-04-11     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  871-7     Citation Subset:  IM    
Affiliation:
Department of Cardiac Surgery, AHEPA University Hospital, Thessaloniki, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Aortic Aneurysm, Thoracic / blood,  immunology*,  radiography
Aortography / methods
Biological Markers / blood
C-Reactive Protein / metabolism*
Disease Progression
Female
Humans
Inflammation Mediators / blood*
Interleukin-6 / blood*
Male
Middle Aged
Predictive Value of Tests
Prognosis
Risk Factors
Time Factors
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Biological Markers; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Interleukin-6; 9007-41-4/C-Reactive Protein
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