Document Detail


C-Phycocyanin inhibits cell proliferation and may induce apoptosis in human HepG2 cells.
MedLine Citation:
PMID:  20306699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
C-Phycocyanin (C-Pc) is one of the major biliprotein pigments of unicellular cyanbacterium of Spirulina platenesis, it has nutritional, medicinal, and hepatoprotectant application. The growth and multiplication of human hepatoma cell lines (HepG2) under the effect of different concentrations of C-PC (0.8, 1.75, 3.5 and 7.0 microg/ml) against untreated cells as control for 24h were investigated. The results showed that the proliferating cells in presence of C-PC reached 70, 51, 44, and 39%, respectively. The results revealed that the greatest reduction in proliferation of cells was recorded at 7.0 microg/ml and LC50 at 1.75 microg/ml of C-PC. In parallel, to the previous results HCl-denatured MG-P revealed that in mass of cells there is a pattern of apoptosis because the expanded cytoplasmic area (bluish-green) reduced and appeared faintly red as C-PC concentration increased. Moreover, the cells lost all the nuclear entities then, become fragmented and having no nuclear remnants. The C-PC may be a new potential anti-cancer drug for therapy of human hepatoma cells.
Authors:
Osama M Basha; Raghda A Hafez; Yassin M El-Ayouty; Karima F Mahrous; Mohammed H Bareedy; Ahmed M Salama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Egyptian journal of immunology / Egyptian Association of Immunologists     Volume:  15     ISSN:  1110-4902     ISO Abbreviation:  Egypt J Immunol     Publication Date:  2008  
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9816016     Medline TA:  Egypt J Immunol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  161-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / drug effects*
Cell Proliferation / drug effects*
Cell Survival / drug effects
DNA Fragmentation / drug effects
Dose-Response Relationship, Drug
Electrophoresis, Agar Gel
Hep G2 Cells
Humans
Phycocyanin / pharmacology*
Spirulina / metabolism
Chemical
Reg. No./Substance:
11016-15-2/Phycocyanin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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