| C-PR neuron of Aplysia has differential effects on "Feeding" cerebral interneurons, including myomodulin-positive CBI-12. | |
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MedLine Citation:
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PMID: 10036256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Head lifting and other aspects of the appetitive central motive state that precedes consummatory feeding movements in Aplysia is promoted by excitation of the C-PR neuron. Food stimuli activate C-PR as well as a small population of cerebral-buccal interneurons (CBIs). We wished to determine if firing of C-PR produced differential effects on the various CBIs or perhaps affected all the CBIs uniformly as might be expected for a neuron involved in producing a broad undifferentiated arousal state. We found that when C-PR was fired, it produced a wide variety of effects on various CBIs. Firing of C-PR evoked excitatory input to a newly identified CBI (CBI-12) the soma of which is located in the M cluster near the previously identified CBI-2. CBI-12 shares certain properties with CBI-2, including a similar morphology and a capacity to drive rhythmic activity of the buccal-ganglion. Unlike CBI-2, CBI-12 exhibits myomodulin immunoreactivity. Furthermore when C-PR is fired, CBI-12 receives a polysynaptic voltage-dependent slow excitation, whereas, CBI-2 receives relatively little input. C-PR also polysynaptically excites other CBIs including CBI-1 and CBI-8/9 but produces inhibition in CBI-3. In addition, firing of C-PR inhibits plateau potentials in CBI-5/6. The data suggest that activity of C-PR may promote the activity of one subset of cerebral-buccal interneurons, perhaps those involved in ingestive behaviors that occur during the head-up posture. C-PR also inhibits some cerebral-buccal interneurons that may be involved in behaviors in which C-PR activity is not required or may even interfere with other feeding behaviors such as rejection or grazing, that occur with the head down. |
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Authors:
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I Hurwitz; R Perrins; Y Xin; K R Weiss; I Kupfermann |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neurophysiology Volume: 81 ISSN: 0022-3077 ISO Abbreviation: J. Neurophysiol. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-08-17 Completed Date: 1999-08-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 521-34 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York 10029, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aplysia Cell Size / physiology Central Nervous System / physiology* Evoked Potentials / physiology Feeding Behavior / physiology* Ganglia, Invertebrate / physiology Interneurons / cytology, metabolism, physiology* Neural Inhibition / physiology Neural Pathways / physiology Neurons / cytology, physiology* Neuropeptides / metabolism* Patch-Clamp Techniques |
| Grant Support | |
ID/Acronym/Agency:
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GM-320099/GM/NIGMS NIH HHS; MH-36730/MH/NIMH NIH HHS; MH-50235/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptides; 110570-93-9/myomodulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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