Document Detail


C-PR neuron of Aplysia has differential effects on "Feeding" cerebral interneurons, including myomodulin-positive CBI-12.
MedLine Citation:
PMID:  10036256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Head lifting and other aspects of the appetitive central motive state that precedes consummatory feeding movements in Aplysia is promoted by excitation of the C-PR neuron. Food stimuli activate C-PR as well as a small population of cerebral-buccal interneurons (CBIs). We wished to determine if firing of C-PR produced differential effects on the various CBIs or perhaps affected all the CBIs uniformly as might be expected for a neuron involved in producing a broad undifferentiated arousal state. We found that when C-PR was fired, it produced a wide variety of effects on various CBIs. Firing of C-PR evoked excitatory input to a newly identified CBI (CBI-12) the soma of which is located in the M cluster near the previously identified CBI-2. CBI-12 shares certain properties with CBI-2, including a similar morphology and a capacity to drive rhythmic activity of the buccal-ganglion. Unlike CBI-2, CBI-12 exhibits myomodulin immunoreactivity. Furthermore when C-PR is fired, CBI-12 receives a polysynaptic voltage-dependent slow excitation, whereas, CBI-2 receives relatively little input. C-PR also polysynaptically excites other CBIs including CBI-1 and CBI-8/9 but produces inhibition in CBI-3. In addition, firing of C-PR inhibits plateau potentials in CBI-5/6. The data suggest that activity of C-PR may promote the activity of one subset of cerebral-buccal interneurons, perhaps those involved in ingestive behaviors that occur during the head-up posture. C-PR also inhibits some cerebral-buccal interneurons that may be involved in behaviors in which C-PR activity is not required or may even interfere with other feeding behaviors such as rejection or grazing, that occur with the head down.
Authors:
I Hurwitz; R Perrins; Y Xin; K R Weiss; I Kupfermann
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurophysiology     Volume:  81     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-08-17     Completed Date:  1999-08-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  521-34     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York 10029, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aplysia
Cell Size / physiology
Central Nervous System / physiology*
Evoked Potentials / physiology
Feeding Behavior / physiology*
Ganglia, Invertebrate / physiology
Interneurons / cytology,  metabolism,  physiology*
Neural Inhibition / physiology
Neural Pathways / physiology
Neurons / cytology,  physiology*
Neuropeptides / metabolism*
Patch-Clamp Techniques
Grant Support
ID/Acronym/Agency:
GM-320099/GM/NIGMS NIH HHS; MH-36730/MH/NIMH NIH HHS; MH-50235/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Neuropeptides; 110570-93-9/myomodulin

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