Document Detail


C/EBP and C-Myb sites are important for the functional activity of the human myeloperoxidase upstream enhancer.
MedLine Citation:
PMID:  18435917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myeloperoxidase (MPO), an enzyme active against bacterial and fungal infections, is expressed specifically in myeloblasts and promyelocytes and minimal in other cell types. We recently identified and partially characterized an upstream enhancer located between -4100 and -3844 bp of the MPO gene. We showed that an AML1 site contributes to enhancer activity and specificity. We now demonstrate three additional footprints within the MPO enhancer and provide evidence that C/EBP and c-Myb sites contribute to its functional, tissue-specific activity. This distal enhancer appears to play an important role in the control of MPO transcription during differentiation of myeloid cells.
Authors:
Congjun Yao; Zhenyu Qin; Kimberly N Works; Garth E Austin; Andrew N Young
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Publication Detail:
Type:  Journal Article     Date:  2008-04-22
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  371     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-16     Completed Date:  2008-06-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  IM    
Affiliation:
Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Decatur, GA 30033, USA.
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MeSH Terms
Descriptor/Qualifier:
Binding Sites
CCAAT-Enhancer-Binding Proteins / chemistry,  genetics,  metabolism*
Cell Line, Tumor
Deoxyribonuclease I / chemistry
Enhancer Elements, Genetic*
Gene Expression Regulation*
Genes, Reporter
Humans
Peroxidase / genetics*
Protein Footprinting
Proto-Oncogene Proteins c-myb / chemistry,  genetics,  metabolism*
Chemical
Reg. No./Substance:
0/CCAAT-Enhancer-Binding Proteins; 0/Proto-Oncogene Proteins c-myb; EC 1.11.1.7/Peroxidase; EC 3.1.21.1/Deoxyribonuclease I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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