Document Detail


A C-H Borylation Approach to Suzuki-Miyaura Coupling of Typically Unstable 2-Heteroaryl and Polyfluorophenyl Boronates.
MedLine Citation:
PMID:  22853624     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A method for the synthesis of biaryls and heterobiaryls from arenes and haloarenes without the intermediacy of unstable boronic acids is described. Pinacol boronate esters that are analogous to unstable boronic acids are formed in high yield by iridium-catalyzed C-H borylation of heteroarenes and fluoroarenes. These boronates are stable in the solid state or in solution and can be generated and used in situ. They couple with aryl halides in the presence of simple palladium catalysts, providing a convenient route to biaryl and heteroaryl products that have been challenging to prepare via boronic acids.
Authors:
Daniel W Robbins; John F Hartwig
Related Documents :
11329684 - Anaerobic codigestion of municipal solid waste and biosolids under various mixing condi...
12395184 - Aromatic amino acid biosynthesis and production of related compounds from p-hydroxyphen...
22404424 - In situ supramolecular assembly and modular modification of hyaluronic acid hydrogels f...
3958144 - Quantitative gas chromatographic analysis of volatile fatty acids in spent culture medi...
9558444 - A role for lipoxygenase metabolites of arachidonic acid in porcine ovulation.
11112604 - Easy access to 3,8-diaryldifurano[2,3-a:2',3'-f]naphthalenes. a new extended aromatic s...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-2
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, University of Illinois , Urbana-Champaign, Urbana, Illinois 61801, United States, and University of California , Department of Chemistry, Berkeley, California 94720, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reduced Newcastle disease virus-induced oncolysis in a subpopulation of cisplatin-resistant MCF7 cel...
Next Document:  Syntheses and Magnetic Properties Study of Isostructural BiM(2)BP(2)O(10) (M = Co, Ni) Containing a ...