| Bystander activation by cytokines of intrahepatic T cells in chronic viral hepatitis. | |
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MedLine Citation:
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PMID: 9408967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although immune responses to hepatitis viruses are initiated by virus-specific T cells, there is evidence that many more intrahepatic T cells are activated than those specific for the pathogen. Recent evidence suggests that cytokine combinations, such as IL-2, IL-6, and TNF alpha, can activate both naive and memory T cells in vitro. The inflammatory cytokine milieu in the liver of patients with chronic viral hepatitis may therefore favor bystander activation of T cells. This may play an important role in enhancing effector T-cell function in the liver, and in maintaining peripheral memory T cells in the absence of antigenic stimulation, such as after virus clearance. |
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Authors:
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S Abrignani |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in liver disease Volume: 17 ISSN: 0272-8087 ISO Abbreviation: Semin. Liver Dis. Publication Date: 1997 |
Date Detail:
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Created Date: 1998-01-29 Completed Date: 1998-01-29 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8110297 Medline TA: Semin Liver Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 319-22 Citation Subset: IM |
Affiliation:
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IRIS, Research Centre of Chiron Vaccines, Siena, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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CD4-Positive T-Lymphocytes
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immunology Cytokines / biosynthesis, immunology* Hepatitis, Chronic / immunology* Hepatitis, Viral, Human / immunology* Humans Immunity, Cellular / physiology Interleukin-2 / biosynthesis, immunology Interleukin-6 / biosynthesis, immunology T-Lymphocytes / immunology* Tumor Necrosis Factor-alpha / biosynthesis, immunology |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin-2; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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