Document Detail


Butyrylcholinesterase activity in women with diabetes mellitus in pregnancy: correlation with antioxidant activity.
MedLine Citation:
PMID:  20143968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of: 25 women with gestational diabetes, 25 with type 2 diabetes, 21 with healthy pregnancies and 15 non-pregnant healthy controls were investigated to evaluate the relationship between butyrylcholinesterase activity and antioxidant status in the serum and placenta of diabetic pregnant women. Levels of antioxidant activities were estimated by Randox Kits and malondialdehyde and butyrylcholinesterase by colorimetric methods. Butyrylcholinesterase activity was elevated in the serum and placenta in normal pregnancy vs diabetic cohorts (p < 0.01) and there was a higher activity level in gestational and type 2 diabetes on insulin (p < 0.05) compared with diet controlled. There was higher malondialdehyde and lower antioxidant activity in diet vs insulin controlled diabetes (p < 0.01). Serum and placental butyrylcholinesterase activity showed a strong inverse correlation with malondialdehyde (r = -0.876, p < 0.001) and (r = 0.542, p < 0.01), but strong positive correlation with total antioxidant activity in serum (r = 0.764, p < 0.001) and placenta (r = 0.642, p < 0.01). Butyrylcholinesterase may therefore, be involved in reducing oxidative stress in diabetic pregnancy.
Authors:
A E Omu; M K Al-Azemi; F E Omu; T Fatinikun; S Abraham; S George; N Mahnazhath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  30     ISSN:  1364-6893     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-10     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  122-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Faculty of Medicine, Kuwait University, Safat, Kuwait. Omu@hsc.edu.kw
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / analysis
Butyrylcholinesterase / blood*
Cross-Sectional Studies
Diabetes Mellitus, Type 2 / blood*
Diabetes, Gestational / blood*
Female
Humans
Lipid Peroxidation*
Malondialdehyde / blood
Placenta / metabolism*
Pregnancy
Pregnancy in Diabetics / blood*
Prospective Studies
Young Adult
Chemical
Reg. No./Substance:
0/Antioxidants; 542-78-9/Malondialdehyde; EC 3.1.1.-/Butyrylcholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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