Document Detail

Butyrylcholinesterase K variant and cerebral amyloid angiopathy.
MedLine Citation:
PMID:  9836756     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Cholinesterases are found histochemically in the vessels affected with cerebral amyloid angiopathy (CAA). A gene for the K variant of butyrylcholinesterase (BCHE-K) may be associated with late-onset Alzheimer's disease (AD). In search of genetic risk factors for CAA, we investigated the association of BCHE-K with CAA.
METHODS: The association between the severity of CAA and BCHE-K was investigated in 155 autopsy cases of the elderly, including 48 patients with AD.
RESULTS: There was no significant association of BCHE-K with the severity of CAA in the total, AD, or non-AD cases. Status of the epsilon4 allele of apolipoprotein E gene did not influence the results.
CONCLUSIONS: Our results may suggest that BCHE-K is not a definitive risk factor for CAA in the elderly, although further study with larger samples is necessary to confirm this.
M Yamada; N Sodeyama; Y Itoh; N Suematsu; E Otomo; M Matsushita; H Mizusawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  29     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-01-08     Completed Date:  1999-01-08     Revised Date:  2014-02-06    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2488-90     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / enzymology,  genetics
Apolipoprotein E4
Apolipoproteins E / genetics
Butyrylcholinesterase / genetics*,  metabolism*
Cerebral Amyloid Angiopathy / enzymology*,  genetics
Gene Frequency
Genetic Variation*
Isoenzymes / metabolism
Middle Aged
Reg. No./Substance:
0/Apolipoprotein E4; 0/Apolipoproteins E; 0/Isoenzymes; EC 3.1.1.-/Butyrylcholinesterase

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