| Butyrophilin-like 2 in pulmonary sarcoidosis: a factor for susceptibility and progression? | |
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MedLine Citation:
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PMID: 21256912 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aims of this study were to assess the association of BTNL2 G16071A with the course of pulmonary sarcoidosis and verify association with disease predisposition. In addition, the linkage between BTNL2 G16071A and certain HLA-DRB1/DQB1 types was investigated. In a retrospective case-control study BTNL2 G16071A, HLA-DQB1 and DRB1 were typed in 632 sarcoidosis patients. These patients were classified into 304 patients with persistent and 328 patients with non-persistent sarcoidosis. The BTNL2 16071A variant allele was significantly more often present in patients with persistent disease (92.4%; 281/304) compared with patients demonstrating a non-persistent course (86.6%; 284/328); odds ratio (OR) =1.89 with 95% confidence interval (CI 95%): 1.11-3.22. Furthermore, BTNL2 16071A variant allele carriers have an increased risk (OR=1.85, CI 95%: 1.19-2.88) to develop sarcoidosis. Moreover, the strong linkage between variant allele and HLA-DRB1*15 presence (OR=8.43, CI 95%: 3.02-23.5) was confirmed. The presence of a BTNL2 G16071A variant allele almost doubles the risk of progressing to persistent pulmonary sarcoidosis, besides increasing the risk to develop sarcoidosis. Presumably, these increased risks are due to the strong linkage between BTNL2 G16071A and DRB1*15. The choice between determining BTNL2 G16071A SNP or the HLA-DRB1 type depends on the ability and/or availability to perform either test. |
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Authors:
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Petal A Wijnen; Christina E Voorter; Patty J Nelemans; Johny A Verschakelen; Otto Bekers; Marjolein Drent |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-20 |
Journal Detail:
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Title: Human immunology Volume: - ISSN: 1879-1166 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010936 Medline TA: Hum Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Dept. of Clinical Chemistry, Maastricht University Medical Centre (MUMC), Maastricht; Ild care center, MUMC, Maastricht. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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