| Butyric acid increases invasiveness of HL-60 leukemia cells: role of reactive oxygen species. | |
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MedLine Citation:
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PMID: 11997038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Butyric acid (BA) induces differentiation of human leukemia, including HL-60 cells. By using a fluorescent probe, we showed that reactive oxygen species (ROS) were generated in BA-treated cells. BA-induced differentiation was accompanied with an increased secretion of pro-matrix metalloproteinase (MMP)-9. Both phenomena were inhibited by antioxidants. Tissue inhibitors of MMP (TIMP)-1 and -2 secretion were increased by BA, but differently affected by antioxidants. By contrast, BA did not affect MMP-9 mRNA, and decreased TIMP-1 and TIMP-2 mRNA levels. In addition, migratory and invasive properties of HL-60 cells were enhanced by BA, but differently affected by antioxidants. Altogether, these results indicate that ROS are messengers of BA-induced differentiation and increased invasiveness. |
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Authors:
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Doriane Richard; Patrick Hollender; Benoît Chénais |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 518 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-08 Completed Date: 2002-05-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 159-63 Citation Subset: IM |
Affiliation:
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Unité MéDIAN, CNRS FRE-2141, Université de Reims-Champagne Ardenne, Faculté de Pharmacie, 51 rue Cognacq-Jay, F-51096 Cedex, Reims, France. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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pharmacology Butyric Acid / antagonists & inhibitors, pharmacology* Cell Differentiation / drug effects Cell Movement* HL-60 Cells Humans Leukemia, Promyelocytic, Acute / enzymology, metabolism*, pathology Matrix Metalloproteinase 9 / biosynthesis, genetics Neoplasm Invasiveness RNA, Neoplasm / biosynthesis Reactive Oxygen Species / metabolism* Tissue Inhibitor of Metalloproteinases / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/RNA, Neoplasm; 0/Reactive Oxygen Species; 0/Tissue Inhibitor of Metalloproteinases; 107-92-6/Butyric Acid; EC 3.4.24.35/Matrix Metalloproteinase 9 |
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