Document Detail

Butyric acid increases invasiveness of HL-60 leukemia cells: role of reactive oxygen species.
MedLine Citation:
PMID:  11997038     Owner:  NLM     Status:  MEDLINE    
Butyric acid (BA) induces differentiation of human leukemia, including HL-60 cells. By using a fluorescent probe, we showed that reactive oxygen species (ROS) were generated in BA-treated cells. BA-induced differentiation was accompanied with an increased secretion of pro-matrix metalloproteinase (MMP)-9. Both phenomena were inhibited by antioxidants. Tissue inhibitors of MMP (TIMP)-1 and -2 secretion were increased by BA, but differently affected by antioxidants. By contrast, BA did not affect MMP-9 mRNA, and decreased TIMP-1 and TIMP-2 mRNA levels. In addition, migratory and invasive properties of HL-60 cells were enhanced by BA, but differently affected by antioxidants. Altogether, these results indicate that ROS are messengers of BA-induced differentiation and increased invasiveness.
Doriane Richard; Patrick Hollender; Benoît Chénais
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  518     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-08     Completed Date:  2002-05-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  159-63     Citation Subset:  IM    
Unité MéDIAN, CNRS FRE-2141, Université de Reims-Champagne Ardenne, Faculté de Pharmacie, 51 rue Cognacq-Jay, F-51096 Cedex, Reims, France.
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MeSH Terms
Antioxidants / pharmacology
Butyric Acid / antagonists & inhibitors,  pharmacology*
Cell Differentiation / drug effects
Cell Movement*
HL-60 Cells
Leukemia, Promyelocytic, Acute / enzymology,  metabolism*,  pathology
Matrix Metalloproteinase 9 / biosynthesis,  genetics
Neoplasm Invasiveness
RNA, Neoplasm / biosynthesis
Reactive Oxygen Species / metabolism*
Tissue Inhibitor of Metalloproteinases / biosynthesis
Reg. No./Substance:
0/Antioxidants; 0/RNA, Neoplasm; 0/Reactive Oxygen Species; 0/Tissue Inhibitor of Metalloproteinases; 107-92-6/Butyric Acid; EC Metalloproteinase 9

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