| Butyrate stimulates fibronectin synthesis in cultured rabbit cornea. | |
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MedLine Citation:
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PMID: 3980586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To understand corneal wound healing, in which fibronectin plays an important role, we investigated the regulatory mechanism of fibronectin synthesis in cultured rabbit corneal blocks in situ. The amount of fibronectin was determined by enzyme-linked immunosorbent assay. We found that butyrate stimulated fibronectin synthesis in a dose-response fashion, and that butyrate had a greater stimulatory effect than did any of its derivatives examined. This suggests that butyrate stimulates fibronectin synthesis specifically; 8Br-cAMP also stimulated fibronectin synthesis. Additivity of stimulation by butyrate and by 8Br-cAMP was observed at the saturated concentration of each; the present result indicated an independent mechanism of action for these two compounds. |
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Authors:
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H Tanaka; T Nishida |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cellular physiology Volume: 123 ISSN: 0021-9541 ISO Abbreviation: J. Cell. Physiol. Publication Date: 1985 May |
Date Detail:
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Created Date: 1985-05-07 Completed Date: 1985-05-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0050222 Medline TA: J Cell Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 191-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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8-Bromo Cyclic Adenosine Monophosphate
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pharmacology Animals Butyrates / pharmacology* Butyric Acid Butyric Acids / pharmacology* Cornea / drug effects, metabolism* Cycloheximide / pharmacology Dose-Response Relationship, Drug Fatty Acids, Volatile / pharmacology Fibronectins / biosynthesis* Organ Culture Techniques Rabbits Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Butyrates; 0/Butyric Acids; 0/Fatty Acids, Volatile; 0/Fibronectins; 107-92-6/Butyric Acid; 23583-48-4/8-Bromo Cyclic Adenosine Monophosphate; 66-81-9/Cycloheximide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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