Document Detail


Butyramide and monobutyrin: growth inhibitory and differentiating agents.
MedLine Citation:
PMID:  8476205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Butyramide and monobutyrin were chosen for study as neutral compounds that might exhibit some of the growth inhibitory and differentiating effects of butyrate. Inhibitory effects on DNA synthesis in hepatoma cells and on cellular proliferation in mouse erythroleukemia cells were observed. Induction of differentiation by butyramide and monobutyrin was seen in mouse erythroleukemia cells as monitored by increased synthesis of hemoglobin and H1 zero histone. Butyramide and monobutyrin were less effective inducers of hemoglobin synthesis than butyrate but their neutral character may offer an advantage in the induction of tumor cell differentiation.
Authors:
M A Lea; Q Xiao; A Sadhukhan; S Sharma; H L Newmark
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  13     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1993 Jan-Feb
Date Detail:
Created Date:  1993-05-18     Completed Date:  1993-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  145-9     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark 07103.
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MeSH Terms
Descriptor/Qualifier:
Amides / pharmacology*
Animals
Antineoplastic Agents / pharmacology*
Butyric Acid
Butyric Acids / pharmacology
Cell Differentiation / drug effects
Cell Division / drug effects
Glycerides / pharmacology*
Hemoglobins / biosynthesis
Histones / biosynthesis
Humans
Leukemia, Erythroblastic, Acute / drug therapy*,  pathology
Liver Neoplasms, Experimental / drug therapy*,  pathology
Mice
Rats
Chemical
Reg. No./Substance:
0/Amides; 0/Antineoplastic Agents; 0/Butyric Acids; 0/Glycerides; 0/Hemoglobins; 0/Histones; 107-92-6/Butyric Acid; 26999-06-4/1-butyrylglycerol; 541-35-5/butyramide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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