Document Detail

Butyltin compounds in human liver.
MedLine Citation:
PMID:  11908938     Owner:  NLM     Status:  MEDLINE    
Intake of marine food is the main source of butyltin exposure in humans. Health effects following exposure to butyltin compounds are usually in the immune system, but endocrine effects of butyltin from a variety of marine species have been documented. The information on human exposure to butyltin compounds and hepatic deposition is limited. The present study include 18 consecutively sampled human livers analyzed for butyltin compounds. Dibutyltin (DBT) concentrations varied between 0.8 and 28.3 ng/g with a mean concentration of 9.0 ng/g. Significantly lower concentrations of monobutyltin (MBT) were observed, ranging from 0.3 to 4.7 ng/g with a mean value of 1.6 ng/g. Age and DBT/MBT ratio were significantly associated. We suggest that younger men have more recent exposures or have a lower capacity to debutylate DBT than older men and would therefore potentially be more susceptible to butyltin toxicity. Given the interperson variability observed in our limited group of men, we cannot exclude that thresholds for either immunotoxicity or effects on the endocrine system may occur due to exposure to butyltin compounds alone or in combination with other environmental toxicants with similar target organs.
Jesper B Nielsen; Jakob Strand
Related Documents :
17485118 - Quantitative magnetic resonance brain imaging in us army veterans of the 1991 gulf war ...
19086208 - Effects of ingested nano-sized titanium dioxide on terrestrial isopods (porcellio scaber).
19064548 - Exposure to a tobacco-specific lung carcinogen in adolescent versus adult smokers.
6494738 - The role of toxicological interactions in chemical carcinogenesis.
22023788 - Knowledge and awareness of tuberculosis among roma population in belgrade: a qualitativ...
20144628 - Dietary factors in chronic inflammation: food tolerances and intolerances of a new zeal...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental research     Volume:  88     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-03-22     Completed Date:  2002-04-30     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Institute of Public Health, University of Southern Denmark, Odense C, DK-5000, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Aged, 80 and over
Endocrine System / drug effects
Environmental Exposure*
Immune System / drug effects
Liver / chemistry*
Middle Aged
Tissue Distribution
Trialkyltin Compounds / adverse effects,  pharmacokinetics*
Reg. No./Substance:
0/Trialkyltin Compounds; 688-73-3/tributyltin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Exposure of children to lead and cadmium from a mining area of Brazil.
Next Document:  Dichlorodiphenyltrichloroethane in soil, river sediment, and fish in the Amazon in Brazil.