Document Detail


Butyltin compounds in human liver.
MedLine Citation:
PMID:  11908938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intake of marine food is the main source of butyltin exposure in humans. Health effects following exposure to butyltin compounds are usually in the immune system, but endocrine effects of butyltin from a variety of marine species have been documented. The information on human exposure to butyltin compounds and hepatic deposition is limited. The present study include 18 consecutively sampled human livers analyzed for butyltin compounds. Dibutyltin (DBT) concentrations varied between 0.8 and 28.3 ng/g with a mean concentration of 9.0 ng/g. Significantly lower concentrations of monobutyltin (MBT) were observed, ranging from 0.3 to 4.7 ng/g with a mean value of 1.6 ng/g. Age and DBT/MBT ratio were significantly associated. We suggest that younger men have more recent exposures or have a lower capacity to debutylate DBT than older men and would therefore potentially be more susceptible to butyltin toxicity. Given the interperson variability observed in our limited group of men, we cannot exclude that thresholds for either immunotoxicity or effects on the endocrine system may occur due to exposure to butyltin compounds alone or in combination with other environmental toxicants with similar target organs.
Authors:
Jesper B Nielsen; Jakob Strand
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental research     Volume:  88     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-03-22     Completed Date:  2002-04-30     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Affiliation:
Institute of Public Health, University of Southern Denmark, Odense C, DK-5000, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Aged, 80 and over
Endocrine System / drug effects
Environmental Exposure*
Humans
Immune System / drug effects
Liver / chemistry*
Male
Middle Aged
Tissue Distribution
Trialkyltin Compounds / adverse effects,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Trialkyltin Compounds; 688-73-3/tributyltin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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