Document Detail


Bursts in the medial geniculate body: a comparison between anesthetized and unanesthetized states in guinea pig.
MedLine Citation:
PMID:  12898102     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thalamic high frequency bursts have long been described under anesthesia and during slow-wave sleep (SWS). More recently, studies in the lateral geniculate nucleus have pointed out that they are also present during waking (W). Here, we compared the bursts recorded in the medial geniculate body of guinea pigs under anesthesia or during periods of W and SWS. The tuning of single units was tested between threshold and 80 dB SPL in two conditions: (1) in restrained, undrugged, non-sleep-deprived guinea pigs (n=101 cells) and (2) under pentobarbital anesthesia (n=53 cells). Off-line analyses allowed us to distinguish single action potentials (APs) from bursts. A burst was defined as a group of APs with an interspike interval < or =4 ms, preceded by a silent period > or =100 ms. We found that auditory thalamus bursts occur in synchronized electroencephalogram states (SWS and anesthesia), but also during W. Although the burst characteristics did not differ among the three states, group data showed that the proportion of bursts within spike trains was the greatest under anesthesia. This observation resulted from two types of effects: (1) the percentage of non-bursting cells was lowest under anesthesia and (2) some cells under anesthesia exhibited up to 90% of bursts, whereas during W or SWS the highest proportion of bursts did not exceed 40%. The presence of these bursts is discussed with regards to the known fluctuations of membrane potential which occur in these various states.
Authors:
Aurélie Massaux; Jean-Marc Edeline
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-08-01
Journal Detail:
Title:  Experimental brain research     Volume:  153     ISSN:  0014-4819     ISO Abbreviation:  Exp Brain Res     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-21     Completed Date:  2004-03-24     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  573-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Action Potentials / drug effects,  physiology*
Anesthetics / pharmacology*
Animals
Auditory Pathways / cytology,  drug effects,  physiology*
Auditory Perception / drug effects,  physiology
Diazepam / pharmacology
Geniculate Bodies / cytology,  drug effects,  physiology*
Guinea Pigs
Neurons / cytology,  drug effects,  physiology*
Pentobarbital / pharmacology
Sleep / physiology
Wakefulness / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Anesthetics; I4744080IR/Pentobarbital; Q3JTX2Q7TU/Diazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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