Document Detail


Burst firing of action potentials in central snail neurons elicited by d-amphetamine: effect of anticonvulsants.
MedLine Citation:
PMID:  11083032     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of anticonvulsants on the burst firing of action potentials in snail central neuron elicited by d-amphetamine was studied in the identified RP4 neuron of the African snail, Achatina fulica Ferussac. Oscillation of membrane potential and burst firing of action potentials were elicited by d-amphetamine in a concentration-dependent manner. Voltage clamped studies revealed that d-amphetamine elicited a negative slope resistance (NSR) in steady-state I-V curve between - 40 and - 10 mV. The burst firing of action potentials was alleviated following extracellular application of phenytoin, but was not affected after ethosuximide, carbamazepine, and valproic acid. The NSR elicited by d-amphetamine was blocked by phenytoin. However, the NSR was not altered if carbamazepine was added. These results suggest that of the four anticonvulsants tested, only phenytoin could alleviate the burst firing of action potentials elicited by d-amphetamine in snail neuron.
Authors:
Y H Chen; C H Chang; G J Liang; S S Huang; H M Hsieh; C M Teng; M C Tsai
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP     Volume:  127     ISSN:  1532-0456     ISO Abbreviation:  Comp. Biochem. Physiol. C Toxicol. Pharmacol.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2001-02-12     Completed Date:  2001-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100959500     Medline TA:  Comp Biochem Physiol C Toxicol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-31     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, College of Medicine, Vational Taiwan University, Taipei, ROC.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects*,  physiology
Animals
Anticonvulsants / pharmacology*
Central Nervous System / cytology,  drug effects*,  physiology
Dextroamphetamine / pharmacology*
Dose-Response Relationship, Drug
Drug Interactions
Electrophysiology
Ganglia, Invertebrate / cytology,  drug effects,  physiology
Neurons / drug effects*,  physiology
Patch-Clamp Techniques
Phenytoin / pharmacology*
Snails / physiology*
Chemical
Reg. No./Substance:
0/Anticonvulsants; 51-64-9/Dextroamphetamine; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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