Document Detail

Burn and trauma associated proteinuria: the role of lipid peroxidation, renin and myoglobin.
MedLine Citation:
PMID:  3281556     Owner:  NLM     Status:  MEDLINE    
Ten trauma patients and 13 burns patients were studied intensively for the first 36 h and subsequent 6 days post injury in order to investigate the mechanism of trauma and burn associated proteinuria. Burns patient's initial maximum proteinuria occurred between 4 and 8 h post injury, whilst trauma patients showed greatest proteinuria within 4 h. In both groups coexisting myoglobinuria or marked elevation of serum renin activity was not found during the first 36 h. Following admission serum lipid peroxides rose in burns patients reaching a maximum between 2 and 8 h following injury, after which levels fell rapidly; in contrast trauma patient's values were initially within normal limits, but rose sharply after 12 h with peaks occurring between 16 h and 7 days post injury. Some patients within both groups showed a recurrent protein leak 2 to 5 days post injury. The data suggest that myoglobinuria or raised renin levels do not play an important role in trauma associated proteinuria.
P Gosling; A J Sutcliffe; M A Cooper; A F Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  25 ( Pt 1)     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-05-12     Completed Date:  1988-05-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  53-9     Citation Subset:  IM    
Biochemistry Department, Selly Oak Hospital, Birmingham, UK.
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MeSH Terms
Albuminuria / etiology
Burns / complications*
Creatinine / urine
Kidney / metabolism
Lipid Peroxides / blood,  physiology*
Middle Aged
Myoglobin / physiology*
Myoglobinuria / etiology
Proteinuria / metabolism*,  urine
Renin / blood,  physiology*
Thiobarbiturates / urine
Time Factors
Wounds and Injuries / complications*,  metabolism
Reg. No./Substance:
0/Lipid Peroxides; 0/Myoglobin; 0/Thiobarbiturates; 60-27-5/Creatinine; EC

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