| Burn and trauma associated proteinuria: the role of lipid peroxidation, renin and myoglobin. | |
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MedLine Citation:
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PMID: 3281556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ten trauma patients and 13 burns patients were studied intensively for the first 36 h and subsequent 6 days post injury in order to investigate the mechanism of trauma and burn associated proteinuria. Burns patient's initial maximum proteinuria occurred between 4 and 8 h post injury, whilst trauma patients showed greatest proteinuria within 4 h. In both groups coexisting myoglobinuria or marked elevation of serum renin activity was not found during the first 36 h. Following admission serum lipid peroxides rose in burns patients reaching a maximum between 2 and 8 h following injury, after which levels fell rapidly; in contrast trauma patient's values were initially within normal limits, but rose sharply after 12 h with peaks occurring between 16 h and 7 days post injury. Some patients within both groups showed a recurrent protein leak 2 to 5 days post injury. The data suggest that myoglobinuria or raised renin levels do not play an important role in trauma associated proteinuria. |
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Authors:
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P Gosling; A J Sutcliffe; M A Cooper; A F Jones |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of clinical biochemistry Volume: 25 ( Pt 1) ISSN: 0004-5632 ISO Abbreviation: Ann. Clin. Biochem. Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-05-12 Completed Date: 1988-05-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0324055 Medline TA: Ann Clin Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 53-9 Citation Subset: IM |
Affiliation:
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Biochemistry Department, Selly Oak Hospital, Birmingham, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Albuminuria / etiology Burns / complications* Creatinine / urine Female Humans Kidney / metabolism Lipid Peroxides / blood, physiology* Male Middle Aged Myoglobin / physiology* Myoglobinuria / etiology Proteinuria / metabolism*, urine Renin / blood, physiology* Thiobarbiturates / urine Time Factors Wounds and Injuries / complications*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Lipid Peroxides; 0/Myoglobin; 0/Thiobarbiturates; 60-27-5/Creatinine; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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