Document Detail

Burn sera mediated effects on the E-rosetting property of normal active T1 cells.
MedLine Citation:
PMID:  3879194     Owner:  NLM     Status:  MEDLINE    
This study investigates the suppressive effects of burn sera on normal active T1 cells. The results revealed that burn sera collected from survivors and non-survivors during the initial 'shock' phase caused varied effects on the 'E' rosetting properties of normal active T1 cells. However, unlike non-survivor sera convalescent or recovery sera failed to block the 'E' rosetting property of T1 cells. Furthermore, cold incubation in fetal calf sera (FCS) failed to abrogate the loss of T1 cells which were exposed to non-survivor (early) sera; these samples also revealed the presence of antigenic factors. Our experiments were extended to investigate the mechanisms resulting in the irreversible change, and showed that the inhibiting factors could be acting at the microtubular level of the cell cortex.
S S Mistry; N F Mistry; S Arora; N H Antia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Burns, including thermal injury     Volume:  12     ISSN:  -     ISO Abbreviation:  Burns Incl Therm Inj     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-04-15     Completed Date:  1986-04-15     Revised Date:  2014-07-22    
Medline Journal Info:
Nlm Unique ID:  7512054     Medline TA:  Burns Incl Therm Inj     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  97-101     Citation Subset:  IM    
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MeSH Terms
Burns / blood*,  immunology,  mortality
Cell Migration Inhibition
Colchicine / pharmacology
Immunity, Cellular
Leukocytes / immunology
Phytohemagglutinins / pharmacology
Receptors, Immunologic / biosynthesis
Rosette Formation*
T-Lymphocytes / immunology*
Reg. No./Substance:
0/Phytohemagglutinins; 0/Receptors, Immunologic; SML2Y3J35T/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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