Document Detail

Burn patient characteristics and outcomes following resuscitation with albumin.
MedLine Citation:
PMID:  17223485     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Use of colloids in acute burn resuscitation may reduce fluid requirements, but effect on mortality is unknown. We hypothesized that patients who received albumin would have similar mortality to patients who did not receive albumin. METHODS: We performed a case-controlled study of inpatients who sustained burns of > or =20% total body surface area (TBSA). Patients who received albumin during resuscitation because of increased fluid requirements (ALB) were compared to a cohort of patients matched for age and TBSA who did not receive albumin (CON). RESULTS: Patients with inhalation injury were significantly more likely to receive albumin (OR 4.89, 95% CI 2.58-9.30). ALB patients had significantly higher mean initial lactate (3.64 versus 2.29, p=0.01), longer mean time to resuscitation (52.8 h versus 36.3 h; p=0.001), and higher resuscitation volume (9.4 mL/kg/%TBSA versus 6.4 mL/kg/%TBSA for CON). Mortality was not significantly different between the two groups (OR 1.90, 95% CI 0.85-4.22). Albumin was protective in a multivariate model of mortality (OR 0.27, 95% CI 0.07-0.97). CONCLUSIONS: Despite more severe systemic dysfunction, burn patients who received albumin did not suffer increased mortality. A novel finding is the decreased likelihood of mortality associated with the administration of albumin during burn resuscitation.
Amalia Cochran; Stephen E Morris; Linda S Edelman; Jeffrey R Saffle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  33     ISSN:  0305-4179     ISO Abbreviation:  Burns     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-15     Completed Date:  2007-04-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  England    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  IM    
Burn Center at the University of Utah, Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA.
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MeSH Terms
Albumins / therapeutic use*
Burns / mortality,  therapy*
Case-Control Studies
Regression Analysis
Respiration, Artificial / methods
Resuscitation / methods*
Retrospective Studies
Sepsis / etiology
Treatment Outcome
Reg. No./Substance:

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