Document Detail

Burkitt's lymphoma presenting with hypopituitarism: a case report and review of literature.
MedLine Citation:
PMID:  25045522     Owner:  NLM     Status:  PubMed-not-MEDLINE    
LEARNING POINTS: Hypopituitarism may be the presenting symptom of lymphoma in the absence of associated overt symptoms or signs of a haematological malignancy resulting in delay in diagnosis and institution of treatment.Pituitary dysfunction due to tumour infiltration has a greater tendency to involve the posterior pituitary and infundibulum resulting in diabetes insipidus and hyperprolactinaemia compared with a non-functioning pituitary adenoma.The common associated symptoms of hypopituitarism due to lymphoma infiltration of the hypothalamic-pituitary system include painful ophthalmoplegia, cranial nerve palsies and constitutional symptoms.Radiological abnormalities of the hypothalamic-pituitary region are usually present and often associated with cavernous sinus or stalk involvement.With early institution of definitive treatment, both haematological response and improvement of pituitary dysfunction are expected although the reversal of hypopituitarism tends to be partial and delayed.A high index of suspicion of underlying malignancy such as lymphoma should be present in patients presenting with acute pituitary dysfunction associated with painful ophthalmoplegia, radiological features atypical of pituitary adenomas and constitutional symptoms to enable early diagnosis and prompt initiation of definitive therapy.
Siew Hui Foo; Shahada A H Sobah
Publication Detail:
Type:  Journal Article     Date:  2014-07-01
Journal Detail:
Title:  Endocrinology, diabetes & metabolism case reports     Volume:  2014     ISSN:  2052-0573     ISO Abbreviation:  Endocrinol Diabetes Metab Case Rep     Publication Date:  2014  
Date Detail:
Created Date:  2014-07-21     Completed Date:  2014-07-21     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  101618943     Medline TA:  Endocrinol Diabetes Metab Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  140029     Citation Subset:  -    
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