| Burkitt's Leukemia with an Atypical Immunophenotype: Report of a Case and Review of Literature. | |
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MedLine Citation:
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PMID: 22189212 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Burkitt's leukemia (BL) constitutes a small but important fraction of acute leukemias in children. It is an aggressive type of leukemia that is responsive to high-intensity, short-duration chemotherapy with complete remission possible in 75% to 90% of cases. The recognition and proper designation of BL is important because treatment differs from that of precursor B-cell acute lymphoblastic leukemia (pre-B ALL). Burkitt's leukemia is separated by its typical morphologic features (blasts with typical French-American-British [FAB] L-3 morphology compared to FAB L-1/L-2 morphology in pre-B ALL) and a classic immunophenotype (blast positivity for CD45 [bright], CD20 [bright], CD10, CD19, surface immunoglobulin [SIg], Ig light chain restriction, and negative terminal deoxynucleotidyl transferase [TdT]) compared to pre-B ALL blasts (which are positive for CD45 [dim], CD10, CD19, and TdT and negative for CD20 and SIg). The diagnosis of Burkitt's leukemia is confirmed by the characteristic cytogenetic findings.The combination of Burkitt's morphology with precursor B-cell immunophenotype may present a diagnostic pitfall, resulting in delay of proper management.We describe such an atypical case in a 12-year-old girl and emphasize that correct classification and treatment starts with proper morphologic/immunophenotypic correlation, and the awareness of the overlapping features in some cases. |
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Authors:
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Neil J Rawlinson; Peter Baker; Samir B Kahwash |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Laboratory hematology : official publication of the International Society for Laboratory Hematology Volume: 17 ISSN: 1523-6528 ISO Abbreviation: Lab Hematol Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9615688 Medline TA: Lab Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 27-31 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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