Document Detail

Burkitt's Leukemia with an Atypical Immunophenotype: Report of a Case and Review of Literature.
MedLine Citation:
PMID:  22189212     Owner:  NLM     Status:  In-Data-Review    
Burkitt's leukemia (BL) constitutes a small but important fraction of acute leukemias in children. It is an aggressive type of leukemia that is responsive to high-intensity, short-duration chemotherapy with complete remission possible in 75% to 90% of cases. The recognition and proper designation of BL is important because treatment differs from that of precursor B-cell acute lymphoblastic leukemia (pre-B ALL). Burkitt's leukemia is separated by its typical morphologic features (blasts with typical French-American-British [FAB] L-3 morphology compared to FAB L-1/L-2 morphology in pre-B ALL) and a classic immunophenotype (blast positivity for CD45 [bright], CD20 [bright], CD10, CD19, surface immunoglobulin [SIg], Ig light chain restriction, and negative terminal deoxynucleotidyl transferase [TdT]) compared to pre-B ALL blasts (which are positive for CD45 [dim], CD10, CD19, and TdT and negative for CD20 and SIg). The diagnosis of Burkitt's leukemia is confirmed by the characteristic cytogenetic findings.The combination of Burkitt's morphology with precursor B-cell immunophenotype may present a diagnostic pitfall, resulting in delay of proper management.We describe such an atypical case in a 12-year-old girl and emphasize that correct classification and treatment starts with proper morphologic/immunophenotypic correlation, and the awareness of the overlapping features in some cases.
Neil J Rawlinson; Peter Baker; Samir B Kahwash
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory hematology : official publication of the International Society for Laboratory Hematology     Volume:  17     ISSN:  1523-6528     ISO Abbreviation:  Lab Hematol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615688     Medline TA:  Lab Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  27-31     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
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