| Burkitt Lymphoma Arising From Lymphoplasmacytic Lymphoma Following Acquisition of MYC Translocation and Loss of the ETV6 Tumor Suppressor Gene. | |
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MedLine Citation:
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PMID: 23276184 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Lymphoplasmacytic lymphoma is a mature B-cell lymphoma with variable plasmacytic differentiation that displays an indolent clinical course. Its transformation to a high-grade B-cell lymphoma may occur uncommonly. Although acquisition of a MYC translocation could result in transformation of a low-grade lymphoma into diffuse large B-cell lymphoma, Burkitt lymphoma, or B-lymphoblastic leukemia, to our knowledge the latter 2 transformations have not been well documented in lymphoplasmacytic lymphoma. We report the case of a 70-year-old woman with a 9-year history of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia who presented with rapid enlargement of a left neck mass and pancytopenia, which was diagnosed as Burkitt lymphoma with extensive bone marrow involvement. A series of histopathologic, molecular, and cytogenetic evaluations proved a cytogenetic evolution including t(8;14)(q24;q32)/MYC-IgH and identical clonal B-cell gene rearrangements from the 2 distinct lymphomas, confirming stage 4 aggressive Burkitt lymphoma arising from lymphoplasmacytic lymphoma. |
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Authors:
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Deniz Peker; Brian Quigley; Dahui Qin; Peter Papenhausen; Ling Zhang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 137 ISSN: 1543-2165 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: United States |
Other Details:
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Languages: eng Pagination: 130-3 Citation Subset: AIM; IM |
Affiliation:
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From the Department of Hematopathology & Laboratory Medicine, Moffitt Cancer Center, Tampa, Florida (Drs Peker, Qin, and Zhang); the Department of Anatomic Pathology, University of South Florida, Tampa (Dr Quigley); and the Genetics Department, LabCorp Diagnostics, Research Triangle Park, North Carolina (Dr Papenhausen). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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