Document Detail


Burkholderia cepacia is associated with pulmonary hypertension and increased mortality among cystic fibrosis patients.
MedLine Citation:
PMID:  15583278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to evaluate the impact of Burkholderia cepacia on cardiovascular status and mortality in cystic fibrosis. Seven patients infected with B. cepacia were matched with 31 patients not infected with this organism for gender, age, height, weight, genotype, and percent predicted forced expiratory volume in one second, partial arterial oxygen pressure, and pancreatic sufficiency status. The pulmonary artery systolic pressure, as assessed by transthoracic echocardiography, was significantly higher in patients infected with B. cepacia (61.3 +/- 17.2 mm Hg) than in controls (37.3 +/- 13.9 mm Hg; P = 0.02), and the mean acceleration time was significantly lower (77 +/- 33 ms versus 108 +/- 25 ms; P = 0.02). The 6-month mortality was significantly higher in patients infected with B. cepacia (57% versus 16%; P = 0.02). Six of the seven patients infected with B. cepacia harbored the same ribotype (genomovar II, B. multivorans). Pulmonary hypertension was significantly more frequent in patients infected by B. cepacia and could contribute to the increased mortality rate.
Authors:
Brigitte Fauroux; Nicholas Hart; Samira Belfar; Michèle Boulé; Isabelle Tillous-Borde; Damien Bonnet; Edouard Bingen; Annick Clément
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  42     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-07     Completed Date:  2005-02-02     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5537-41     Citation Subset:  IM    
Affiliation:
Paediatric Pulmonary Department and Research Unit INSERM E 213, Armand Trousseau Hospital, 28 avenue du Docteur Arnold Netter, 75012 Paris, France. brigitte.fauroux@trs.ap-hop-paris.fr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Burkholderia Infections / complications*,  microbiology
Burkholderia cepacia / classification,  genetics,  isolation & purification*
Child
Cystic Fibrosis / microbiology*,  mortality*
Echocardiography
Female
Forced Expiratory Volume
Humans
Hypertension, Pulmonary / etiology*
Male
Respiratory Function Tests
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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