Document Detail


Burden of malaria during pregnancy in areas of stable and unstable transmission in Ethiopia during a nonepidemic year.
MedLine Citation:
PMID:  12751034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Little is known about the epidemiology of malaria during pregnancy in areas of unstable (epidemic-prone) transmission (UT) in sub-Saharan Africa. In cross-sectional studies, peripheral malaria parasitemia was identified in 10.4% of women attending antenatal care clinics at 1 stable transmission (ST) site and in 1.8% of women at 3 UT sites; parasitemia was associated with anemia in both ST (relative risk [RR], 2.0; P<.001) and UT (RR, 4.4; P<.001) sites. Placental parasitemia was identified more frequently during deliveries at ST sites (12/185; 6.5%) than at UT sites (21/833; 2.5%; P=.006). Placental parasitemia was associated with low birth weight at the ST site (RR, 3.2; P=.01) and prematurity at ST (RR, 2.7; P=.04) and UT (RR, 3.9; P=.01) sites and with a 7-fold increased risk of stillbirths at UT sites. The effectiveness and efficiency in Ethiopia of standard preventive strategies used in high-transmission regions (such as intermittent preventive treatment) may require further evaluation; approaches such as insecticide-treated bednets and epidemic preparedness may be needed to prevent adverse pregnancy outcomes.
Authors:
Robert D Newman; Afework Hailemariam; Daddi Jimma; Abera Degifie; Daniel Kebede; Aafje E C Rietveld; Bernard L Nahlen; John W Barnwell; Richard W Steketee; Monica E Parise
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2003-05-15
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  187     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-16     Completed Date:  2003-06-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1765-72     Citation Subset:  AIM; IM    
Affiliation:
Malaria Epidemiology, National Center for Infectious Diseases, and Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA. ren5@cdc.gov
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia / complications,  drug therapy
Animals
Antimalarials / therapeutic use
Ethiopia / epidemiology
Female
Fetal Death / complications
Humans
Infant, Low Birth Weight
Infant, Newborn
Malaria, Falciparum / complications*,  drug therapy,  epidemiology,  transmission*
Malaria, Vivax / complications*,  drug therapy,  epidemiology,  transmission*
Male
Obstetric Labor, Premature / complications
Parasitemia / complications
Placenta / parasitology
Plasmodium falciparum / isolation & purification
Plasmodium vivax / isolation & purification
Pregnancy
Pregnancy Complications, Parasitic / drug therapy,  epidemiology*,  parasitology
Pregnancy Outcome
Grant Support
ID/Acronym/Agency:
U50/CCU012445/CC/CDC HHS
Chemical
Reg. No./Substance:
0/Antimalarials
Comments/Corrections
Comment In:
J Infect Dis. 2003 Oct 15;188(8):1259-61; author reply 1561-2   [PMID:  14551900 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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