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Burden of illness of the 2009 pandemic of influenza A (H1N1) in Denmark.
MedLine Citation:
PMID:  21757107     Owner:  NLM     Status:  In-Data-Review    
We analysed Danish surveillance data to estimate influenza-associated morbidity and mortality in 2009. To obtain population-based estimates of the clinical attack rate, we combined data from two different primary health care surveillance systems, national numbers of the proportion of positive influenza tests, and data from a web-based interview on health care seeking behaviour during the pandemic. From a national registry, we obtained data on hospital admissions (ICD-10 codes) for influenza related conditions. Admission to intensive care was monitored by a dedicated surveillance scheme. Mortality was estimated among laboratory confirmed cases but was also expressed as excess all-cause mortality attributed to influenza-like illness in a multivariable time series analysis. In total, we estimated that 274,000 individuals (5%) in Denmark experienced clinical illness. The highest attack rate was found in children 5-14 years (15%). Compared with the expected number of hospital admissions, there was an 80% increase in number of influenza related hospital admissions in this age group. The numbers of patients admitted to intensive care approached 5% of the national capacity. Estimates of the number of deaths ranged from 30 to 312 (0.5-5.7 per 100,000 population) depending on the methodology. In conclusion, the pandemic was characterised by high morbidity and unprecedented high rates of admissions to hospitals for a range of influenza-related conditions affecting mainly children. Nonetheless, the burden of illness was lower than assumed in planning scenarios, and the present pandemic compares favourable with the 20th century pandemics.
Kåre Mølbak; Katarina Widgren; Klaus Skovbo Jensen; Steen Ethelberg; Peter H Andersen; Annette H Christiansen; Hanne-Dorthe Emborg; Sophie Gubbels; Katja Majlund Harder; Tyra Grove Krause; Anne Mazick; Lars Peter Nielsen; Jens Nielsen; Palle Valentiner-Branth; Steffen Glismann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Vaccine     Volume:  29 Suppl 2     ISSN:  1873-2518     ISO Abbreviation:  Vaccine     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  B63-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Department of Epidemiology, Statens Serum Institut, Copenhagen, Denmark.
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