Document Detail


Bupropion-induced angioedema.
MedLine Citation:
PMID:  18714109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: A case of angioedema caused by bupropion used for smoking cessation is discussed. SUMMARY: A 33-year-old man with a 12-pack-year of smoking history developed a rash on his extremities 18 days after the initiation of bupropion, followed by pruritus and swelling of the arms, feet, lower lip, and tongue by day 20. Progression subsided after treatment with intravenous histamine antagonists and corticosteroids and required two emergency department visits. On day 22, the patient took his morning dose of bupropion as scheduled, which resulted in his symptoms returning. He discontinued bupropion on his own. The recommendation to discontinue the drug was not made or documented by the treating clinician. By day 23, the diarrhea had subsided, the next day his swelling disappeared, and by day 25, the pruritus had ceased. Cases of angioedema, a rare adverse effect of bupropion, have not been extensively described in previous literature. The reaction is linked to medications in 90% of all cases. Nonpitting edema typically affects the head and neck and may progress to respiratory failure. Failure to remove the causative agent may increase patient risk and result in increased health care costs, both of which occurred in this case. According to the Naranjo et al. probability scale, bupropion was deemed a definitive causative agent for this adverse reaction. CONCLUSION: A 33-year-old man developed angioedema during treatment with bupropion for smoking cessation.
Authors:
Amy E Tackett; Kelly M Smith
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists     Volume:  65     ISSN:  1535-2900     ISO Abbreviation:  Am J Health Syst Pharm     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-20     Completed Date:  2008-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503023     Medline TA:  Am J Health Syst Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1627-30     Citation Subset:  IM    
Affiliation:
University of Kentucky College of Pharmacy, Lexington, USA. aetack2@uky.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adrenal Cortex Hormones / administration & dosage
Adult
Angioedema / chemically induced*,  drug therapy
Antidepressive Agents, Second-Generation / administration & dosage,  adverse effects,  therapeutic use
Bupropion / administration & dosage,  adverse effects*
Drug Hypersensitivity / drug therapy,  etiology
Exanthema / chemically induced,  drug therapy
Histamine Agonists / administration & dosage
Humans
Injections, Intravenous
Male
Smoking Cessation / methods
Tobacco Use Disorder / drug therapy*
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Antidepressive Agents, Second-Generation; 0/Histamine Agonists; 34841-39-9/Bupropion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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