Document Detail

Bupropion: congenital heart defects (continued).
MedLine Citation:
PMID:  22515134     Owner:  NLM     Status:  In-Process    
Bupropion, an amphetamine, is authorised as an aid to smoking cessation, despite its negative harm-benefit balance. In 2004, data from a registry of pregnancies exposed to bupropion drew attention to an increased risk of congenital heart defects. In 2010, a case-control study including more than 10 000 children showed a higher incidence of in utero exposure to bupropion among children who had congenital left heart defects. Other, less reliable studies did not show such a link. In practice, this risk of congenital heart defects is yet another reason to avoid using bupropion, including during pregnancy, and to monitor the cardiac status of exposed fetuses and newborns.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prescrire international     Volume:  21     ISSN:  1167-7422     ISO Abbreviation:  Prescrire Int     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9439295     Medline TA:  Prescrire Int     Country:  France    
Other Details:
Languages:  eng     Pagination:  97     Citation Subset:  T    
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