Document Detail


Bupropion can close KATP channel and induce insulin secretion.
MedLine Citation:
PMID:  23348218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently, a case of newborn infant with transient hyperinsulinism has been reported. This infant was reported to be free from typical perinatal risk factors of hyperinsulinism except for the fact that the mother of the baby was receiving the antidepressant bupropion during her pregnancy. However, the mother did not experience hyperinsulinism and, so far, there are no reports about the pharmacological mechanism of bupropion causing hyperinsulinemia. In this study, bupropion was shown to inhibit KATP channel activity in pancreatic β-cell membranes and induce insulin secretion in relatively high concentration. This study shows, for the first time, that bupropion has a direct electrophysiological action on pancreatic β-cells and can cause insulin secretion and also highlights the risk of using bupropion during pregnancy.
Authors:
Yifei Yang; Kenju Shimomura; Kazuya Sakuma; Yuko Maejima; Yusaku Iwasaki; Juris Galvanovskis; Katsuya Dezaki; Masanori Nakata; Toshihiko Yada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  26     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2013  
Date Detail:
Created Date:  2013-04-24     Completed Date:  2013-08-06     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  343-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antidepressive Agents, Second-Generation / adverse effects,  pharmacology
Bupropion / adverse effects,  pharmacology*
Female
Humans
Hyperinsulinism / chemically induced,  metabolism
Infant, Newborn
Insulin / secretion
Insulin-Secreting Cells / drug effects*,  metabolism,  secretion
Ion Channel Gating / drug effects*
Male
Membrane Potentials / drug effects
Mice
Mice, Inbred ICR
Potassium Channel Blockers / adverse effects,  pharmacology*
Potassium Channels / metabolism*
Pregnancy
Grant Support
ID/Acronym/Agency:
084655//Wellcome Trust
Chemical
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Insulin; 0/Potassium Channel Blockers; 0/Potassium Channels; 0/mitochondrial K(ATP) channel; 01ZG3TPX31/Bupropion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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