Document Detail

Bupropion (amfebutamone): caution during pregnancy.
MedLine Citation:
PMID:  16400747     Owner:  HSR     Status:  MEDLINE    
(1) Bupropion, which is also called amfebutamone, is an amphetamine marketed to assist with smoking withdrawal. (2) A registry of pregnancies exposed to bupropion has shown a higher-than-expected frequency of neonatal cardiac malformations: 7 of the 10 newborns with malformations had cardiac anomalies (70% of malformations), compared to about 25% in the general population. (3) An increased risk of birth defects, particularly cardiac malformations, is also suspected after exposure to amphetamine derivatives during pregnancy. (4) In practice, these disturbing data are one more reason not to use bupropion, a drug with a negative risk-benefit balance, even outside of pregnancy.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prescrire international     Volume:  14     ISSN:  1167-7422     ISO Abbreviation:  Prescrire Int     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-01-09     Completed Date:  2006-02-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9439295     Medline TA:  Prescrire Int     Country:  France    
Other Details:
Languages:  eng     Pagination:  225     Citation Subset:  T    
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MeSH Terms
Amphetamines / adverse effects,  therapeutic use
Antidepressive Agents, Second-Generation / adverse effects,  therapeutic use
Bupropion / adverse effects*,  contraindications,  therapeutic use
Congenital Abnormalities / etiology*
Dopamine Uptake Inhibitors / adverse effects,  therapeutic use
Heart Defects, Congenital / chemically induced*
Infant, Newborn
Pregnancy / drug effects*
Smoking Cessation
Reg. No./Substance:
0/Amphetamines; 0/Antidepressive Agents, Second-Generation; 0/Dopamine Uptake Inhibitors; 34841-39-9/Bupropion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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