| Buprenorphine suppresses heroin use by heroin addicts. | |
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MedLine Citation:
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PMID: 7352279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heroin-dependent men were given buprenorphine (a partial opiate agonist-antagonist) or a placebo under duoble-blind conditions on a clinical research ward where they could acquire heroin (21 to 40.5 milligrams per day, intravenously). Buprenorphine significantly (P less than .001) suppressed the self-administration of heroin over 10 days. Control subjects took between 93 and 100 percent of the available heroin. The effects of buprenorphine were dose-dependent; a dose of 8 milligrams per day reduced heroin use by 69 to 98 percent; a dose of 4 milligrams per day reduced heroin use by 45 percent. Termination of buprenorphie maintenance did not result in opiate withdrawal signs or symptoms. The subjects liked buprenorphine and indicated that it was preferable to methadone or naltrexone. Buprenorphine should be a safe and effective new pharmacotherapy for heroin dependence. |
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Authors:
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N K Mello; J H Mendelson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 207 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1980 Feb |
Date Detail:
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Created Date: 1980-03-17 Completed Date: 1980-03-17 Revised Date: 2007-03-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 657-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Buprenorphine / adverse effects, therapeutic use* Double-Blind Method Heroin Dependence / drug therapy* Humans Informed Consent Morphinans / therapeutic use* Substance Withdrawal Syndrome / prevention & control Substance-Related Disorders / prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Morphinans; 52485-79-7/Buprenorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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