Document Detail

Buprenorphine-associated gastroparesis during in-patient heroin detoxification.
MedLine Citation:
PMID:  17298658     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Buprenorphine is a partial mu receptor agonist used in opiate detoxification. It has been shown to cause delayed gastric emptying in healthy volunteers. CASE DESCRIPTION: We describe a case of clinically severe gastroparesis (delayed gastric emptying due to impaired contraction of the stomach) whose onset coincided with the commencement of buprenorphine-assisted detoxification. CONCLUSION: We review the literature on gastric effects of buprenorphine in healthy volunteers, providing proof of the concept that this was the most probable cause of this patient's gastroparesis.
Simon L Jakobovits; Michael McDonough; Robert Y Chen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Addiction (Abingdon, England)     Volume:  102     ISSN:  0965-2140     ISO Abbreviation:  Addiction     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-14     Completed Date:  2007-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304118     Medline TA:  Addiction     Country:  England    
Other Details:
Languages:  eng     Pagination:  490-1     Citation Subset:  IM    
Department of Gastroenterology, Western Hospital Footscray, Gordon Street Footscray, 3011, Victoria, Australia.
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MeSH Terms
Buprenorphine / adverse effects*
Gastroparesis / chemically induced*
Heroin Dependence / drug therapy*
Narcotic Antagonists / therapeutic use*
Reg. No./Substance:
0/Narcotic Antagonists; 52485-79-7/Buprenorphine

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