| Buprenorphine enhances and prolongs the postoperative analgesic effect of bupivacaine in patients receiving infragluteal sciatic nerve block. | |
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MedLine Citation:
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PMID: 21042200 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Results from previous studies have shown favorable effects from the addition of buprenorphine to local anesthetics used for interscalene or axillary perivascular brachial plexus blocks. The main objective of the current study was to determine whether addition of buprenorphine could enhance bupivacaine analgesia after infragluteal sciatic nerve block. METHODS: One hundred and three consenting adult patients for elective foot and ankle outpatient surgeries were prospectively assigned randomly, in double-blind fashion, to one of three groups. Group 1 received 0.5% bupivacaine with epinephrine 1:200,000 for infragluteal sciatic block plus 1 ml normal saline intramuscularly. Group 2 received bupivacaine sciatic block along with intramuscular buprenorphine (0.3 mg). Group 3 received bupivacaine plus buprenorphine for infragluteal sciatic block and 1 ml normal saline intramuscularly. RESULTS: Although patients receiving buprenorphine either for sciatic block or intramuscularly had less pain in the postanesthesia care unit compared with patients receiving only bupivacaine, the individual pair-wise comparison of the analysis of variance model showed no statistical difference. However, only buprenorphine added to bupivacaine for sciatic block prolonged postoperative analgesia. Patients receiving a combination of buprenorphine and bupivacaine for sciatic block had lower numeric rating pain scores and received less opioid medication at home than patients in the other two groups. CONCLUSIONS: The results show that buprenorphine may enhance and prolong the analgesic effect of bupivacaine when used for sciatic nerve blocks in patients undergoing foot and ankle surgery under general anesthesia but does not do so to the extent shown in previous studies using brachial plexus models with mepivacaine and tetracaine. |
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Authors:
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Kenneth D Candido; Jason Hennes; Sergio Gonzalez; Marianne Mikat-Stevens; Michael Pinzur; Vladimir Vasic; Nebojsa Nick Knezevic |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anesthesiology Volume: 113 ISSN: 1528-1175 ISO Abbreviation: Anesthesiology Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 1419-26 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, Illinois 60657, USA. kdcandido@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ambulatory Surgical Procedures Analgesics, Opioid / administration & dosage, therapeutic use* Anesthetics, Local* Ankle / surgery Bupivacaine* Buprenorphine / administration & dosage, therapeutic use* Double-Blind Method Female Foot / surgery Humans Injections, Intramuscular Male Middle Aged Nerve Block* Orthopedic Procedures Pain Measurement Pain, Postoperative / drug therapy* Patient Satisfaction Postoperative Nausea and Vomiting / epidemiology Preanesthetic Medication Sciatic Nerve* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Anesthetics, Local; 2180-92-9/Bupivacaine; 52485-79-7/Buprenorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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