Document Detail

Bupivacaine-induced seizures and ventricular fibrillation in a 13-year-old girl undergoing wound debridement.
MedLine Citation:
PMID:  9814406     Owner:  NLM     Status:  MEDLINE    
Bupivacaine is a commonly used local anesthetic in dental, ophthalmologic, and simple surgical procedures. Its current popularity derives from its potency and relatively long half-life. Widespread use of bupivacaine has resulted in sometimes severe adverse reactions when significant systemic absorption has occurred. This report documents a life-threatening event following use of bupivacaine, briefly reviews its neurotoxic and cardiotoxic effects, and raises questions about current management strategies when toxicity occurs.
A C Yan; R D Newman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric emergency care     Volume:  14     ISSN:  0749-5161     ISO Abbreviation:  Pediatr Emerg Care     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-08     Completed Date:  1999-01-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8507560     Medline TA:  Pediatr Emerg Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  354-5     Citation Subset:  IM    
Department of Pediatrics, Children's Hospital and Medical Center and the University of Washington, Seattle, USA.
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MeSH Terms
Acute Disease
Anesthetics, Local / adverse effects*
Anticonvulsants / adverse effects,  therapeutic use
Bupivacaine / adverse effects*
Diazepam / adverse effects,  therapeutic use
Drug Synergism
Seizures / chemically induced*,  drug therapy
Ventricular Fibrillation / chemically induced*,  therapy
Wounds and Injuries / surgery*
Reg. No./Substance:
0/Anesthetics, Local; 0/Anticonvulsants; 2180-92-9/Bupivacaine; 439-14-5/Diazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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