Document Detail

Bupivacaine combined with isoflurane synergistically depressed myocardial contractility in rat working heart preparation.
MedLine Citation:
PMID:  9283198     Owner:  NLM     Status:  MEDLINE    
It is well known that both local and volatile anesthetics depress myocardial functions. This study was performed to evaluate the combined effects of commonly utilized local anesthetics (bupivacaine, mepivacaine, and lidocaine) and a volatile anesthetic (isoflurane) on heart rate and myocardial contractility in an isolated rat working heart preparation using each local anesthetic at 0 to 3 x 10(-4) (mol/L) with or without 1 MAC (minimum alveolar concentration) of isoflurane. The three local anesthetics depressed the heart rate and myocardial contractility dose-dependent. Bupivacaine depressed the heart rate more than the other two local anesthetics. One MAC isoflurane showed significant negative inotropic effects, and accelerated the effects of the local anesthetics. By using isobolographic analysis, we concluded that the combined effect of isoflurane and bupivacaine on myocardial negative inotropism was synergistic, while the effects of isoflurane and mepivacaine or lidocaine were additive.
T Takamura; A Sakamoto; R Ogawa
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Nihon Ika Daigaku zasshi     Volume:  64     ISSN:  0048-0444     ISO Abbreviation:  Nippon Ika Daigaku Zasshi     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-11-25     Completed Date:  1997-11-25     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  7505726     Medline TA:  Nihon Ika Daigaku Zasshi     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  292-7     Citation Subset:  IM    
Department of Anesthesiology, Nippon Medical School, Tokyo, Japan.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Anesthetics, Local / pharmacology*
Bupivacaine / pharmacology*
Depression, Chemical
Drug Combinations
Drug Synergism
Heart Rate / drug effects
Isoflurane / pharmacology*
Lidocaine / pharmacology
Mepivacaine / pharmacology
Myocardial Contraction / drug effects*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Local; 0/Drug Combinations; 137-58-6/Lidocaine; 2180-92-9/Bupivacaine; 26675-46-7/Isoflurane; 96-88-8/Mepivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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