Document Detail


Bundle-branch block in middle-aged men: risk of complications and death over 28 years. The Primary Prevention Study in Göteborg, Sweden.
MedLine Citation:
PMID:  16214833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To investigate the long-term fate of men with bundle-branch block (BBB) from a general population sample. METHODS AND RESULTS: Data were derived from 7392 men without a history of myocardial infarction or stroke, born between 1915 and 1925 and investigated between 1970 and 1973. All participants were followed from the date of their baseline examination until 1998. We identified 70 men with right-BBB and 46 men with left-BBB at baseline. In men with right-BBB, there was no increased risk of myocardial infarction, coronary death, heart failure, or all-cause mortality during follow-up. The multiple-adjusted hazard ratio for progression to high-degree atrioventricular block was 3.64 (99% confidence interval 0.79-16.72). In men with left-BBB, the hazard ratio for high-degree atrioventricular block was 12.89 (4.13-40.24). However, hazard ratio for all-cause mortality was 1.85 (1.15-2.97) when compared with men without BBB, mostly due to outside hospital coronary deaths, whose hazard ratio was 4.22 (1.90-9.34). CONCLUSION: The presence of BBB was strongly associated with future high-degree atrioventricular block that was more pronounced for left-BBB. Men with left-BBB have a substantially increased risk of coronary death, mainly due to sudden death outside the hospital setting.
Authors:
Peter Eriksson; Lars Wilhelmsen; Annika Rosengren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-10-07
Journal Detail:
Title:  European heart journal     Volume:  26     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-17     Completed Date:  2006-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  2300-6     Citation Subset:  IM    
Affiliation:
Clinical Experimental Research Lab, The Cardiovascular Institute, Göteborg University, Drakeg 6, SE-41250 Göteborg, Sweden. peter.eriksson@vgregion.se
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MeSH Terms
Descriptor/Qualifier:
Bundle-Branch Block / complications,  mortality*,  prevention & control
Death, Sudden, Cardiac / epidemiology*,  prevention & control
Electrocardiography
Epidemiologic Methods
Humans
Male
Middle Aged
Myocardial Ischemia / mortality
Prognosis
Sweden / epidemiology
Comments/Corrections
Comment In:
Eur Heart J. 2005 Nov;26(21):2222-3   [PMID:  16214834 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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