Document Detail


Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy.
MedLine Citation:
PMID:  23061490     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of γ-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing responses to GABA. In the current pilot study we provide the first documented look at efficacy of bumetanide, a specific NKCC1 antagonist, on reduction of seizure frequency in adult patients with temporal lobe epilepsy. According to our results, seizure frequency was reduced considerably in these patients. Furthermore, epileptiform discharges decreased in two of our patients. If the efficacy of bumetanide is proven in large scale studies, it can be used as a supplemental therapy in temporal lobe epilepsy.
Authors:
Sanaz Eftekhari; Jafar Mehvari Habibabadi; Massoumeh Najafi Ziarani; Seyed Sohrab Hashemi Fesharaki; Marzieh Gharakhani; Hossein Mostafavi; Mohammad Taghi Joghataei; Nahid Beladimoghadam; Elham Rahimian; Mahmoud Reza Hadjighassem
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Epilepsia     Volume:  -     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 International League Against Epilepsy.
Affiliation:
Cellular and Molecular Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Shefa Neuroscience Research Center, Tehran, Iran Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Stem Cell Technology Research Center, Molecular Biology and Genetic Engineering Department, Tehran, Iran Zanjan University of Medical Sciences, Zanjan, Iran Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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