Document Detail

Bull's-eyes and halos: useful MR discriminators of osseous metastases.
MedLine Citation:
PMID:  8511306     Owner:  NLM     Status:  MEDLINE    
To evaluate the presence of (a) a focus of high signal intensity in the center of an osseous lesion (bull's-eye) as a negative discriminator for metastasis and (b) a rim of high signal intensity around an osseous lesion (halo) as a positive discriminator, a retrospective study was performed in 47 patients with osseous lesions suspect for metastatic disease who underwent magnetic resonance (MR) imaging of the pelvis. The findings in 17 patients with proved osseous metastasis were compared with those in 30 patients not believed to have metastatic disease; T1- and T2-weighted MR images were evaluated. The bull's-eye sign was found to be a specific indicator of normal hematopoietic marrow (sensitivity, 95%; specificity, 99.5%). The halo sign and diffuse signal hyperintensity were a strong indicator of metastatic disease (sensitivity, 75%; specificity, 99.5%). These results suggest that use of the bull's-eye sign as a discriminator of benign disease and use of the halo sign as a discriminator of metastasis help characterize suspect areas of marrow lesions.
M E Schweitzer; C Levine; D G Mitchell; F H Gannon; L G Gomella
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiology     Volume:  188     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-07-13     Completed Date:  1993-07-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-52     Citation Subset:  AIM; IM    
Department of Radiology, Thomas Jefferson University Hospital, Jefferson Medical College, Philadelphia, PA 19107.
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MeSH Terms
Bone Marrow / pathology*
Bone Neoplasms / diagnosis*,  secondary*
Diagnosis, Differential
Magnetic Resonance Imaging* / statistics & numerical data
Middle Aged
Observer Variation
Pelvic Bones
Retrospective Studies
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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