Document Detail


Bullous mastocytosis: report of a patient and a brief review of the literature.
MedLine Citation:
PMID:  18806488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a 6-month-old male infant who presented to the pediatric dermatology clinic at Wake Forest University Baptist Medical Center with a generalized bullous eruption since 3 months of age. A sepsis work up was performed at an outside hospital before presentation and did not reveal any evidence of systemic infection. Clinical presentation revealed a well-nourished, appropriate-for-age, 6-month-old boy with multiple tense bullae, some in a "string of pearls" arrangement, on the bilateral upper extremities and trunk. Multiple erosions were also noted. Laboratory evaluation revealed a normal complete blood count. Polymerase chain reaction was negative for herpes simplex virus types I and II. Histologic sections demonstrated a large space of separation between the epidermis and dermis which was filled by a monomorphous infiltrate composed of round to oval cells with centrally placed nuclei, consistent with mast cells. Leder and C-Kit stains were strongly positive, confirming the diagnosis of bullous mastocytosis. Treatment included fluocinonide 0.05% cream and tacrolimus 0.1% ointment to active lesions and silver sulfadiazine 1% cream to erosions. Improvement was noted during follow-up examination.
Authors:
Kristina Avshalumov; Rita Pichardo; Joseph L Jorizzo; Omar P Sangueza; Gary Goldenberg
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  30     ISSN:  1533-0311     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2008-12-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  455-7     Citation Subset:  IM    
Affiliation:
Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-Infective Agents, Local / therapeutic use
Fluocinonide / therapeutic use
Glucocorticoids / therapeutic use
Humans
Infant
Male
Mast Cells / metabolism,  pathology
Mastocytosis, Cutaneous / diagnosis*,  drug therapy,  pathology*
Proto-Oncogene Proteins c-kit / metabolism
Silver Sulfadiazine / therapeutic use
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Glucocorticoids; 22199-08-2/Silver Sulfadiazine; 356-12-7/Fluocinonide; EC 2.7.10.1/Proto-Oncogene Proteins c-kit

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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