Document Detail

Bullous lesions in acrodermatitis enteropathica delaying diagnosis of zinc deficiency: a report of two cases and review of the literature.
MedLine Citation:
PMID:  18537855     Owner:  NLM     Status:  MEDLINE    
Acrodermatitis enteropathica (AE) is a rare disorder associated with poor absorption of zinc. A variety of clinical and histological findings have been reported in the literature, described mainly in isolated case reports. Because of the varied nature of these cases, the histological features of AE are described often as non-specific. We describe lesions of AE in two patients who presented with vesiculobullous and erosive skin lesions, both showing intra-epidermal, inflammatory vesiculation with surrounding eosinophilic epidermis and necrotic keratinocytes. The lack of clinical suspicion of AE led to their misdiagnosis. We present these two patients to further characterize the bullous variant of AE, and we review the previously reported clinical and histopathological findings.
Sarah L Jensen; Catherine McCuaig; Artur Zembowicz; Mark A Hurt
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-06-04
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  35 Suppl 1     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-08     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1-13     Citation Subset:  IM    
Copyright Information:
Copyright Blackwell Munksgaard 2008.
Department of Dermatology, Saint Louis University Hospital, St Louis, MO 63104, USA.
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MeSH Terms
Acrodermatitis / pathology*
Blister / pathology*
Dermatitis, Allergic Contact / pathology
Diagnosis, Differential
Diagnostic Errors*
Malabsorption Syndromes / diagnosis*
Zinc / deficiency*
Reg. No./Substance:

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