| Bullous and cicatricial pemphigoid. Clinical, histopathologic, and immunopathologic correlations. | |
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MedLine Citation:
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PMID: 344998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study of the records, biopsies, and immunopathologic data from 84 patients with bullous pemphigoid and 60 patients with cicatricial pemphigoid revealed that patients with bullous pemphigoid and negative or perhaps very low titer of circulating antibasement-membrane antibodies may constitute a distinct subgroup of patients with bullous pemphigoid. This group contained more women than men, had increased mucous membrane involvement, and had higher incidences of hypothyroidism, positive antinuclear antibody tests, and malignancy than did the other patients with bullous pemphigoid. Six of 41 patients with bullous pemphigoid who were given sulfapyridine or dapsone responded to these drugs, and these 6 constitute another group of patients necessitating further study. In nine patients, localized pemphigoid was found. The lesions were of two types: those occurring in sun-exposed areas and those occurring pretibially. Three of 57 patients with cicatricial pemphigoid had circulating antibasement-membrane antibodies. The clinical extent of disease in cicatricial pemphigoid was less extensive in our series than that previously seen at our institution. This was probably due to the earlier and more accurate diagnosis afforded by immunopathologic studies and to wider appreciation of the disease among nondermatologists. |
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Authors:
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J R Person; R S Rogers |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Mayo Clinic proceedings. Mayo Clinic Volume: 52 ISSN: 0025-6196 ISO Abbreviation: Mayo Clin. Proc. Publication Date: 1977 Jan |
Date Detail:
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Created Date: 1978-05-24 Completed Date: 1978-05-24 Revised Date: 2007-10-29 |
Medline Journal Info:
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Nlm Unique ID: 0405543 Medline TA: Mayo Clin Proc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 54-66 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Aged Anti-Inflammatory Agents / therapeutic use Antimalarials / therapeutic use Autoantibodies* / analysis Basement Membrane / immunology Biopsy Cicatrix / pathology Dapsone / therapeutic use Female Fluorescent Antibody Technique Glucocorticoids Humans Immunoglobulins / analysis Immunosuppressive Agents / therapeutic use Male Organ Specificity Prognosis Sex Factors Skin / immunology, pathology Skin Diseases, Vesiculobullous* / diagnosis, drug therapy, immunology, pathology Sulfapyridine / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antimalarials; 0/Autoantibodies; 0/Glucocorticoids; 0/Immunoglobulins; 0/Immunosuppressive Agents; 144-83-2/Sulfapyridine; 80-08-0/Dapsone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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