| Bulk modification of PDMS microchips by an amphiphilic copolymer. | |
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MedLine Citation:
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PMID: 17854125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A simple and rapid bulk-modification method based on adding an amphiphilic copolymer during the fabrication process was employed to modify PDMS microchips. Poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) was used as the additive substance. Compared to the native PDMS microchips, both the contact angle and the EOF of the bulk-modified PDMS microchips decreased. The effects of the additive loading and the pH on the EOF were investigated in detail. The bulk-modified PDMS microchips exhibited reproducible and stable EOF behavior. The application of the bulk-modified PDMS microchips was also studied and the results indicated that they could be successfully used to separate amino acids and to suppress protein adsorption. |
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Authors:
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Yan Xiao; Xiao-Dong Yu; Jing-Juan Xu; Hong-Yuan Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Electrophoresis Volume: 28 ISSN: 0173-0835 ISO Abbreviation: Electrophoresis Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-24 Completed Date: 2007-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8204476 Medline TA: Electrophoresis Country: Germany |
Other Details:
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Languages: eng Pagination: 3302-7 Citation Subset: IM |
Affiliation:
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The Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Dimethylpolysiloxanes
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chemistry* Electrophoresis, Microchip / methods Microscopy, Fluorescence Nylons / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Dimethylpolysiloxanes; 0/Nylons; 0/poly(dimethylsiloxane)-polyamide copolymer |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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