Document Detail

Bulk modification of PDMS microchips by an amphiphilic copolymer.
MedLine Citation:
PMID:  17854125     Owner:  NLM     Status:  MEDLINE    
A simple and rapid bulk-modification method based on adding an amphiphilic copolymer during the fabrication process was employed to modify PDMS microchips. Poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) was used as the additive substance. Compared to the native PDMS microchips, both the contact angle and the EOF of the bulk-modified PDMS microchips decreased. The effects of the additive loading and the pH on the EOF were investigated in detail. The bulk-modified PDMS microchips exhibited reproducible and stable EOF behavior. The application of the bulk-modified PDMS microchips was also studied and the results indicated that they could be successfully used to separate amino acids and to suppress protein adsorption.
Yan Xiao; Xiao-Dong Yu; Jing-Juan Xu; Hong-Yuan Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Electrophoresis     Volume:  28     ISSN:  0173-0835     ISO Abbreviation:  Electrophoresis     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-24     Completed Date:  2007-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8204476     Medline TA:  Electrophoresis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  3302-7     Citation Subset:  IM    
The Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, PR China.
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MeSH Terms
Dimethylpolysiloxanes / chemistry*
Electrophoresis, Microchip / methods
Microscopy, Fluorescence
Nylons / chemistry*
Reg. No./Substance:
0/Dimethylpolysiloxanes; 0/Nylons; 0/poly(dimethylsiloxane)-polyamide copolymer

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