| Bulging fontanelle as presenting sign in cystic fibrosis. Vitamin A metabolism and effect on cerebrospinal fluid pressure. | |
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MedLine Citation:
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PMID: 998579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 51/2-month-old infant had the single problem of a bulging fontanelle. A diagnosis of cystic fibrosis with secondary hypovitaminosis A was made by the findings of high sweat chloride values and a low serum carotene level. A greatly accelerated rate of weight gain following the addition of pancreatic enzyme supplements confirmed the presence of malabsorption. The infant developed characteristic fibrosis pulmonary disease at 20 months of age. Animal studies have shown vitamin A deficiency to be associated with increased cerebrospinal fluid (CSF) pressure, diminished absorption of CSF, and pathological findings of thickening and infiltration with mucopolysaccharides of the dura mater around the arachnoid villi. |
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Authors:
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R S Abernathy |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of diseases of children (1960) Volume: 130 ISSN: 0002-922X ISO Abbreviation: Am. J. Dis. Child. Publication Date: 1976 Dec |
Date Detail:
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Created Date: 1977-01-28 Completed Date: 1977-01-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370471 Medline TA: Am J Dis Child Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1360-2 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Cystic Fibrosis / complications* Diagnosis, Differential Humans Intracranial Pressure* Malabsorption Syndromes / complications Male Skull* Vitamin A / metabolism Vitamin A Deficiency / complications*, diagnosis |
| Chemical | |
Reg. No./Substance:
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11103-57-4/Vitamin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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