Document Detail

Building unique bonds to fight misplaced DNA.
MedLine Citation:
PMID:  23774266     Owner:  NLM     Status:  MEDLINE    
A cyclic dinucleotide comprised of GMP and AMP was previously shown to be a key intermediate during activation of innate immune responses to cytosolic DNA. A report by Patel and Tuschl groups published in Cell reveals the structure of the enzyme involved in the synthesis of this second messenger and identifies this cyclic dinucleotide as a unique compound in metazoan cell signaling.
Caio T Fagundes; Luke A J O'Neill
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Publication Detail:
Type:  Comment; Journal Article     Date:  2013-06-18
Journal Detail:
Title:  Cell research     Volume:  23     ISSN:  1748-7838     ISO Abbreviation:  Cell Res.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-09-02     Completed Date:  2014-04-07     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  9425763     Medline TA:  Cell Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1065-6     Citation Subset:  IM    
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MeSH Terms
Dinucleoside Phosphates / metabolism*
Nucleotides, Cyclic / metabolism*
Nucleotidyltransferases / chemistry*
Second Messenger Systems*
Reg. No./Substance:
0/Dinucleoside Phosphates; 0/Nucleotides, Cyclic; EC 2.7.7.-/Nucleotidyltransferases
Comment On:
Cell. 2013 May 23;153(5):1094-107   [PMID:  23647843 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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