Document Detail


Building and maintaining the epithelium of the lung.
MedLine Citation:
PMID:  22850882     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Airspaces of the lung are lined by an epithelium whose cellular composition changes along the proximal-to-distal axis to meet local functional needs for mucociliary clearance, hydration, host defense, and gas exchange. Advances in cell isolation, in vitro culture techniques, and genetic manipulation of animal models have increased our understanding of the development and maintenance of the pulmonary epithelium. This review discusses basic cellular mechanisms that regulate establishment of the conducting airway and gas exchange systems as well as the functional maintenance of the epithelium during postnatal life.
Authors:
Craig R Rackley; Barry R Stripp
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-08-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-01     Completed Date:  2012-10-25     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2724-30     Citation Subset:  AIM; IM    
Affiliation:
Pulmonary, Allergy and Critical Care, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning
Epithelial Cells / cytology,  physiology
Humans
Lung / cytology,  growth & development*,  physiology*
Mice
Models, Animal
Pulmonary Gas Exchange / physiology
Respiratory Mucosa / growth & development,  physiology
Grant Support
ID/Acronym/Agency:
R21HL106122/HL/NHLBI NIH HHS; T32HL007538/HL/NHLBI NIH HHS; UO1HL111018/HL/NHLBI NIH HHS
Comments/Corrections

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