Document Detail


Building biologics by chemical synthesis: practical preparation of di- and triantennary N-linked glycoconjugates.
MedLine Citation:
PMID:  23461434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A unified strategy for the syntheses of bi- and triantennary fully sialylated N-glycans is described. The synthesis capitalizes on a global glycosylation strategy that delivers the desired undeca- and tetradecasaccharide in excellent yields. Finally, conjugation of the glycan to PSMA oligopeptide is described.
Authors:
Maciej A Walczak; Joji Hayashida; Samuel J Danishefsky
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-03-19
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  135     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-27     Completed Date:  2013-09-09     Revised Date:  2014-03-28    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4700-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Antigens, Surface / chemistry*
Glutamate Carboxypeptidase II / chemical synthesis,  chemistry*
Glycoconjugates / chemical synthesis*,  chemistry
Glycosylation
Oligopeptides / chemical synthesis,  chemistry*
Polysaccharides / chemical synthesis,  chemistry*
Grant Support
ID/Acronym/Agency:
GM102872/GM/NIGMS NIH HHS; R01 GM102872/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Surface; 0/Glycoconjugates; 0/Oligopeptides; 0/Polysaccharides; EC 3.4.17.21/Glutamate Carboxypeptidase II; EC 3.4.17.21/glutamate carboxypeptidase II, human
Comments/Corrections

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