Document Detail


Building-associated neurological damage modeled in human cells: a mechanism of neurotoxic effects by exposure to mycotoxins in the indoor environment.
MedLine Citation:
PMID:  20549560     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Damage to human neurological system cells resulting from exposure to mycotoxins confirms a previously controversial public health threat for occupants of water-damaged buildings. Leading scientific organizations disagree about the ability of inhaled mycotoxins in the indoor environment to cause adverse human health effects. Damage to the neurological system can result from exposure to trichothecene mycotoxins in the indoor environment. This study demonstrates that neurological system cell damage can occur from satratoxin H exposure to neurological cells at exposure levels that can be found in water-damaged buildings contaminated with fungal growth. The constant activation of inflammatory and apoptotic pathways at low levels of exposure in human brain capillary endothelial cells, astrocytes, and neural progenitor cells may amplify devastation to neurological tissues and lead to neurological system cell damage from indirect events triggered by the presence of trichothecenes.
Authors:
Enusha Karunasena; Michael D Larrañaga; Jan S Simoni; David R Douglas; David C Straus
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-13
Journal Detail:
Title:  Mycopathologia     Volume:  170     ISSN:  1573-0832     ISO Abbreviation:  Mycopathologia     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-26     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505689     Medline TA:  Mycopathologia     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  377-90     Citation Subset:  IM    
Affiliation:
Department of Animal & Food Sciences, Texas Tech University, Lubbock, TX 79409, USA. enusha.karunasena@ttuhsc.edu
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MeSH Terms
Descriptor/Qualifier:
Apoptosis*
Astrocytes / drug effects*
Cells, Cultured
Endothelial Cells / drug effects*
Humans
Neural Stem Cells / drug effects*
Stress, Physiological*
Trichothecenes / toxicity*
Chemical
Reg. No./Substance:
0/Trichothecenes; 53126-64-0/satratoxin H

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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