Document Detail


Building addressable libraries: the use of "safety-catch" linkers on microelectrode arrays.
MedLine Citation:
PMID:  21090647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A "safety-catch" linker strategy has been used to site-selectively cleave and characterize molecules from a microelectrode array. The linkers are attached to the array by means of an ester and contain either a protected amine or protected alcohol nucleophile that can be released using acid generated at the microelectrodes.
Authors:
Bo Bi; Karl Maurer; Kevin D Moeller
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-11-19
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  132     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2013-03-25     Completed Date:  2013-09-03     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17405-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Combinatorial Chemistry Techniques
Lactones / chemistry
Microarray Analysis / instrumentation*
Microelectrodes
Small Molecule Libraries / chemistry*
Grant Support
ID/Acronym/Agency:
P41 GM103422/GM/NIGMS NIH HHS; P41 RR000954/RR/NCRR NIH HHS; RR00954/RR/NCRR NIH HHS; RR02004/RR/NCRR NIH HHS; RR05018/RR/NCRR NIH HHS; RR07155/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Lactones; 0/Small Molecule Libraries

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